1-(2-tert-butylphenyl)-4-[(2-methoxyphenyl)carbonyl]piperazine | 1252657-04-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(2-tert-butylphenyl)-4-[(2-methoxyphenyl)carbonyl]piperazine
• 英文别名: [4-(2-Tert-butylphenyl)piperazin-1-yl]-(2-methoxyphenyl)methanone
• CAS: 1252657-04-7
• 化学式: C₂₂H₂₈N₂O₂
• 分子量: 352.477
• InChiKey: QAYSQOXPUMCHAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• DERIVATIVES OF N-ACYL-N'-PHENYLPIPERAZINE USEFUL (INTER ALIA) FOR THE PROPHYLAXIS OR TREATMENT OF DIABETES
  申请人：Kasai Shizuo

  公开号：US20120071489A1

  公开（公告）日：2012-03-22

  The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, which has a superior RBP4-lowering action and is useful as a pharmaceutical composition for the prophylaxis or treatment of a disease or condition mediated by an increase in RBP4.

  本发明涉及一种化合物，其化学式如下所示，其中每个符号如本说明书中所定义，该化合物具有优越的降低RBP4作用，并且可用作预防或治疗由RBP4增加介导的疾病或病况的药物组合物。
• US8853215B2
  申请人：——

  公开号：US8853215B2

  公开（公告）日：2014-10-07
• [EN] DERIVATIVES OF N-ACYL-N'-PHENYLPIPERAZINE USEFUL (INTER ALIA) FOR THE PROPHYLAXIS OR TREATMENT OF DIABETES<br/>[FR] DÉRIVÉS DE N-ACYL-N'-PHÉNYLPIPÉRAZINE UTILES (NOTAMMENT) POUR LA PRÉVENTION OU LE TRAITEMENT DU DIABÈTE
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2010119992A1

  公开（公告）日：2010-10-21

  The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, which has a superior RBP4-lowering action and is useful as a pharmaceutical composition for the prophylaxis or treatment of a disease or condition mediated by an increase in RBP4.