2-phenoxy-6-methoxyquinoline-4-carboxylic acid | 359784-26-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-phenoxy-6-methoxyquinoline-4-carboxylic acid
• 英文别名: 6-Methoxy-2-phenoxyquinoline-4-carboxylic acid
• CAS: 359784-26-2
• 化学式: C₁₇H₁₃NO₄
• 分子量: 295.295
• InChiKey: BGSUCMUUZRXGQD-UHFFFAOYSA-N

物化性质

• 沸点：
  484.0±45.0 °C(Predicted)
• 密度：
  1.318±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  68.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-phenoxy-6-methoxyquinoline-4-carboxylic acid 在 草酰氯 作用下， 反应 24.0h， 以100%的产率得到2-phenoxy-6-methoxyquinoline-4-carbonyl chloride
  参考文献：
  名称：

  Quinoline-4-acetamides as sPLA2 inhibitors

  摘要：

  Quinoline-4-acetamides were designed as potential phospholipase Al inhibitors by structural based method and synthesized. The chemical structures of the obtained compounds were confirmed by elemental analyses, H-1 NMR and MS. Preliminary bioassay study shows that quinoline-4-acetamides display certain inhibition to sPLA(2). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00229-3
• 作为产物：
  描述：

  2-phenoxy-4-methyl-6-methoxyquinoline 在 sodium hydroxide 、 sodium periodate 、 四氧化锇 、 silver nitrate 、 zinc(II) chloride 作用下， 反应 39.0h， 生成 2-phenoxy-6-methoxyquinoline-4-carboxylic acid
  参考文献：
  名称：

  Quinoline-4-acetamides as sPLA2 inhibitors

  摘要：

  Quinoline-4-acetamides were designed as potential phospholipase Al inhibitors by structural based method and synthesized. The chemical structures of the obtained compounds were confirmed by elemental analyses, H-1 NMR and MS. Preliminary bioassay study shows that quinoline-4-acetamides display certain inhibition to sPLA(2). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00229-3