| 1191256-05-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1191256-05-9
• 化学式: C₂₀H₃₀O₇S
• 分子量: 414.52
• InChiKey: PSOJEHFYOAKXQI-GPFWEFOESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.78
• 重原子数：
  28.0
• 可旋转键数：
  8.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  91.29
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  在 碳酸氢钠 、 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 以70 %的产率得到2-((2S,3S,4R,5R)-5-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-4-methoxy-3-((phenylsulfonyl)methyl)tetrahydrofuran-2-yl)acetaldehyde
  参考文献：
  名称：

  [EN] COMPOUNDS AND PROCESSES FOR THE PREPARATION OF ERIBULIN
  [FR] COMPOSÉS ET PROCÉDÉS POUR LA PRÉPARATION D'ÉRIBULINE

  摘要：

  The present invention relates to compounds and a process for the preparation of eribulin. More specifically, the process to prepare the C14- C35 sulfone fragment of eribulin (i.e. compounds of formula I) by reacting a C14-C26 ketone fragment of eribulin (i.e. compounds of formula II) with a C27-C35 sulfonium salt fragment (i.e. compounds of formula III) under Corey-Chaykovsky reaction conditions is explored. The processes to prepare the intermediate C14-C26 ketone (i.e. compounds of formula II), the intermediate C27-C35 sulfonium salt (i.e. compounds of formula III) and the intermediate C27-C35 aldehyde (i.e. compounds of formula IV) arc also disclosed.

  公开号：

  WO2023144733A1
• 作为产物：
  描述：

  、 联硼酸频那醇酯 在 双(三甲基硅烷基)氨基钾 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 以30 %的产率得到
  参考文献：
  名称：

  [EN] COMPOUNDS AND PROCESSES FOR THE PREPARATION OF ERIBULIN
  [FR] COMPOSÉS ET PROCÉDÉS POUR LA PRÉPARATION D'ÉRIBULINE

  摘要：

  The present invention relates to compounds and a process for the preparation of eribulin. More specifically, the process to prepare the C14- C35 sulfone fragment of eribulin (i.e. compounds of formula I) by reacting a C14-C26 ketone fragment of eribulin (i.e. compounds of formula II) with a C27-C35 sulfonium salt fragment (i.e. compounds of formula III) under Corey-Chaykovsky reaction conditions is explored. The processes to prepare the intermediate C14-C26 ketone (i.e. compounds of formula II), the intermediate C27-C35 sulfonium salt (i.e. compounds of formula III) and the intermediate C27-C35 aldehyde (i.e. compounds of formula IV) arc also disclosed.

  公开号：

  WO2023144733A1

文献信息

• Second Generation Synthesis of C27−C35 Building Block of E7389, a Synthetic Halichondrin Analogue
  作者：Yu-Rong Yang、Dae-Shik Kim、Yoshito Kishi

  DOI：10.1021/ol9016589

  日期：2009.10.15

  A practical method is reported to synthesize E7389 C27−C35 building block 13 from 1,2-O-isopropylidene-α-d-5-deoxyglucurono-6,3-lactone (3). This synthesis relies on two key processes: (1) C34/C35-diol is introduced via asymmetric dihydroxylation with dr = 3:1, with the undesired C34-diastereomer effectively removed by crystallization of 11, and (2) the C30 PhSO2CH2 group is introduced stereoselectively

  据报道，从 1,2 - O-异亚丙基-α- d -5-脱氧葡萄糖醛酸-6,3-内酯合成 E7389 C27-C35 结构单元13的实用方法( 3 )。该合成依赖于两个关键过程：(1) 通过不对称二羟基化引入 C34/C35-二醇，dr = 3:1，通过11的结晶有效去除不需要的 C34-非对映异构体，以及 (2) C30 PhSO 2 CH在 Crabtree 催化剂的存在下，通过12 的氢化以立体选择性 (>100:1) 引入2基团。报告的合成实际上没有色谱分离。