(4,4-difluoro-piperidin-1-yl)-[3-isopropyl-6-(1-isopropyl-piperidin-4-yloxy)-5-methyl-benzofuran-2-yl]-methanone | 1106538-65-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: (4,4-difluoro-piperidin-1-yl)-[3-isopropyl-6-(1-isopropyl-piperidin-4-yloxy)-5-methyl-benzofuran-2-yl]-methanone
• 英文别名: (4,4-Difluoropiperidin-1-yl)-[5-methyl-3-propan-2-yl-6-(1-propan-2-ylpiperidin-4-yl)oxy-1-benzofuran-2-yl]methanone
• CAS: 1106538-65-1
• 化学式: C₂₆H₃₆F₂N₂O₃
• 分子量: 462.58
• InChiKey: SJWCTVVRVZEIKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  45.9
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• BENZOFURAN AND BENZOTHIOPHENE-2-CARBOXYLIC ACID AMIDE DERIVATIVES
  申请人：Mohr Peter

  公开号：US20090029976A1

  公开（公告）日：2009-01-29

  The present invention relates to compounds of formula I wherein X, A and R 1 to R 4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

  本发明涉及公式I的化合物，其中X，A和R1至R4如描述和索赔中所定义，并且其药学上可接受的盐。这些化合物可用于治疗和/或预防与H3受体调节相关的疾病。
• BENZOFURAN- AND BENZO[B]THIOPHENE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AND USE THEREOF AS HISTAMINE 3 RECEPTOR MODULATORS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2183237A1

  公开（公告）日：2010-05-12
• US7534788B2
  申请人：——

  公开号：US7534788B2

  公开（公告）日：2009-05-19
• [EN] BENZOFURAN- AND BENZO[B]THIOPHENE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AND USE THEREOF AS HISTAMINE 3 RECEPTOR MODULATORS<br/>[FR] DÉRIVÉS D'AMIDE D'ACIDE BENZOFURANE- ET BENZO[B]THIOPHÈNE-2-CARBOXYLIQUE ET LEUR UTILISATION COMME MODULATEURS DU RÉCEPTEUR H3 DE L'HISTAMINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2009013195A1

  公开（公告）日：2009-01-29

  The present invention relates to compounds of formula (I) wherein X, A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.