(S)-4-(1,4-dioxaspiro[4.5]decan-2-yl)butan-1-ol | 1220326-91-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-4-(1,4-dioxaspiro[4.5]decan-2-yl)butan-1-ol
• 英文别名: 4-[(3S)-1,4-dioxaspiro[4.5]decan-3-yl]butan-1-ol
• CAS: 1220326-91-9
• 化学式: C₁₂H₂₂O₃
• 分子量: 214.305
• InChiKey: GTFRYSCHXNMOQR-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S)-4-(1,4-dioxaspiro[4.5]decan-2-yl)butan-1-ol 在 2-碘酰基苯甲酸 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of a diarylheptanoid, (+)-centrolobine

  摘要：

  A chiron approach for the total synthesis of (+)-centrolobine has been described from the commercially available aldehyde 3 employing an acid-catalyzed stereoselective formation of tetrahydropyran ring as the key step The desired molecule was accomplished in eight steps with 62% overall yield (c) 2010 Elsevier Ltd. All rights reserved

  DOI：

  10.1016/j.tetasy.2010.01.002
• 作为产物：
  描述：

  (S)-2-(4-(benzyloxy)but-1-enyl)-1,4-dioxaspiro[4.5]-decane 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 反应 8.0h， 以98%的产率得到(S)-4-(1,4-dioxaspiro[4.5]decan-2-yl)butan-1-ol
  参考文献：
  名称：

  Synthesis of a diarylheptanoid, (+)-centrolobine

  摘要：

  A chiron approach for the total synthesis of (+)-centrolobine has been described from the commercially available aldehyde 3 employing an acid-catalyzed stereoselective formation of tetrahydropyran ring as the key step The desired molecule was accomplished in eight steps with 62% overall yield (c) 2010 Elsevier Ltd. All rights reserved

  DOI：

  10.1016/j.tetasy.2010.01.002

文献信息

• Synthesis of a diarylheptanoid, (+)-centrolobine
  作者：Ch. Raji Reddy、P. Phani Madhavi、S. Chandrasekhar

  DOI：10.1016/j.tetasy.2010.01.002

  日期：2010.1

  A chiron approach for the total synthesis of (+)-centrolobine has been described from the commercially available aldehyde 3 employing an acid-catalyzed stereoselective formation of tetrahydropyran ring as the key step The desired molecule was accomplished in eight steps with 62% overall yield (c) 2010 Elsevier Ltd. All rights reserved