(1S,8S,10R,12R)-15,15-dimethyl-9-oxa-3-azatetracyclo[10.2.1.01,10.03,8]pentadecan-2-one | 1197869-97-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1S,8S,10R,12R)-15,15-dimethyl-9-oxa-3-azatetracyclo[10.2.1.01,10.03,8]pentadecan-2-one
• CAS: 1197869-97-8
• 化学式: C₁₅H₂₃NO₂
• 分子量: 249.353
• InChiKey: WFKZCIJAJYGHAQ-FJJYHAOUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  ((1S,2R,4R)-2-hydroxy-7,7-dimethylbicyclo[2.2.1]heptan-1-yl)(piperidin-1-yl)methanone 在 N,N,N,N-tetraethylammonium tetrafluoroborate 作用下， 以 乙醇 、 乙腈 为溶剂， 以67%的产率得到(1S,8S,10R,12R)-15,15-dimethyl-9-oxa-3-azatetracyclo[10.2.1.01,10.03,8]pentadecan-2-one
  参考文献：
  名称：

  Highly diastereoselective synthesis of pyrido[2,1-b][1,3]oxazin-4(6H)-one by intramolecular anodic oxidation

  摘要：

  This paper describes a method for the intramolecular anodic oxidation of omega-hydroxyl amides. Products were obtained in acceptable yields from different starting materials using various applied currents, charge, and reactant concentrations. Compounds 1a and 1d afforded a single diastereomer in 67% yield when the applied current and reactant concentration were 100 mA and 0.04 M. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.08.017

文献信息

• Highly diastereoselective synthesis of pyrido[2,1-b][1,3]oxazin-4(6H)-one by intramolecular anodic oxidation
  作者：Dong-Sheng Lee

  DOI：10.1016/j.tetasy.2009.08.017

  日期：2009.9

  This paper describes a method for the intramolecular anodic oxidation of omega-hydroxyl amides. Products were obtained in acceptable yields from different starting materials using various applied currents, charge, and reactant concentrations. Compounds 1a and 1d afforded a single diastereomer in 67% yield when the applied current and reactant concentration were 100 mA and 0.04 M. (C) 2009 Elsevier Ltd. All rights reserved.