N1,N2-Dimethyl-N1-[[4-(1-methylethyl)phenyl]methyl]-1,2-ethanediamine | 1096348-44-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: N1,N2-Dimethyl-N1-[[4-(1-methylethyl)phenyl]methyl]-1,2-ethanediamine
• 英文别名: N,N'-dimethyl-N'-[(4-propan-2-ylphenyl)methyl]ethane-1,2-diamine
• CAS: 1096348-44-5
• 化学式: C₁₄H₂₄N₂
• mdl: MFCD12167688
• 分子量: 220.35
• InChiKey: ZPZJQAZGPGTVSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Substituted acethydrazide derivative, preparation method and use thereof
  申请人：Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

  公开号：US10196346B2

  公开（公告）日：2019-02-05

  The present invention pertains to the field of pharmaceutical chemicals, and relates to a substituted acethydrazide derivative, preparation method and use thereof; preferably, relates to a compound of Formula I or a pharmaceutically acceptable salt thereof. The compound of the present invention or a pharmaceutically acceptable salt thereof can effectively inhibit proline hydroxylase, stabilize HIF-α, particularly HIF-1α, and has potency in the manufacture of a medicament for treatment and/or prophylaxis and/or adjuvant therapy of anemia, acute ischemic reperfusion injury.

  本发明涉及医药化工领域，涉及一种取代乙酰肼衍生物及其制备方法和用途；优选地，涉及一种式I化合物或其药学上可接受的盐。本发明的化合物或其药学上可接受的盐能有效抑制脯氨酸羟化酶，稳定HIF-α，特别是HIF-1α，在制造治疗和/或预防和/或辅助治疗贫血、急性缺血再灌注损伤的药物方面具有有效性。
• SUBSTITUTED ACETOHYDRAZIDE DERIVATIVES, PREPARATION METHOD THEREFOR AND USE
  申请人：Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

  公开号：EP3150576B1

  公开（公告）日：2019-07-10
• A Substituted Acethydrazide Derivative, Preparation Method and Use Thereof
  申请人：Institute of Pharmacology and Toxicology Academy of Millitary Medical Sciences P.L.A. China

  公开号：US20170190656A1

  公开（公告）日：2017-07-06

  The present invention pertains to the field of pharmaceutical chemicals, and relates to a substituted acethydrazide derivative, preparation method and use thereof; preferably, relates to a compound of Formula I or a pharmaceutically acceptable salt thereof. The compound of the present invention or a pharmaceutically acceptable salt thereof can effectively inhibit proline hydroxylase, stabilize HIF-α, particularly HIF-1α, and has potency in the manufacture of a medicament for treatment and/or prophylaxis and/or adjuvant therapy of anemia, acute ischemic reperfusion injury.
• SUBSTITUTED ACETHYDRAZIDE DERIVATIVE, PREPARATION METHOD AND USE THEREOF
  申请人：Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

  公开号：US20180134653A1

  公开（公告）日：2018-05-17

  The present invention pertains to the field of pharmaceutical chemicals, and relates to a substituted acethydrazide derivative, preparation method and use thereof; preferably, relates to a compound of Formula I or a pharmaceutically acceptable salt thereof. The compound of the present invention or a pharmaceutically acceptable salt thereof can effectively inhibit proline hydroxylase, stabilize HIF-α, particularly HIF-1α, and has potency in the manufacture of a medicament for treatment and/or prophylaxis and/or adjuvant therapy of anemia, acute ischemic reperfusion injury.