4-(2,4-Difluorophenylamino)-7-methoxy-6-(2-(piperidin-1-yl)ethylamino)quinoline-3-carboxamide | 1130354-39-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(2,4-Difluorophenylamino)-7-methoxy-6-(2-(piperidin-1-yl)ethylamino)quinoline-3-carboxamide
• 英文别名: 4-(2,4-difluoroanilino)-7-methoxy-6-(2-piperidin-1-ylethylamino)quinoline-3-carboxamide
• CAS: 1130354-39-0
• 化学式: C₂₄H₂₇F₂N₅O₂
• 分子量: 455.507
• InChiKey: IQRQPBXCRBANDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  92.5
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  ethyl 4-((2,4-difluorophenyl)amino)-7-methoxy-6-((2-(piperidin-1-yl)ethyl)amino)quinoline-3-carboxylate 在 sodium methylate 、 formamide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 4-(2,4-Difluorophenylamino)-7-methoxy-6-(2-(piperidin-1-yl)ethylamino)quinoline-3-carboxamide
  参考文献：
  名称：

  Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase

  摘要：

  3-Amido-4-anilinoquinolines are potent and highly selective inhibitors of CSF-1R. Their synthesis and SAR is reported, along with initial efforts to optimize the physical properties and PK through modi. cations at the quinoline 6- and 7-positions. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.046

文献信息

• Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase
  作者：David A. Scott、Carrie L. Balliet、Donald J. Cook、Audrey M. Davies、Thomas W. Gero、Charles A. Omer、Srinivasu Poondru、Maria-Elena Theoclitou、Boris Tyurin、Michael J. Zinda

  DOI：10.1016/j.bmcl.2008.12.046

  日期：2009.2

  3-Amido-4-anilinoquinolines are potent and highly selective inhibitors of CSF-1R. Their synthesis and SAR is reported, along with initial efforts to optimize the physical properties and PK through modi. cations at the quinoline 6- and 7-positions. (c) 2008 Elsevier Ltd. All rights reserved.