7-chloro-N-[(3-chlorophenyl)methylideneamino]quinolin-4-amine | 71429-12-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-chloro-N-[(3-chlorophenyl)methylideneamino]quinolin-4-amine
• CAS: 71429-12-4
• 化学式: C₁₆H₁₁Cl₂N₃
• 分子量: 316.189
• InChiKey: XRKYRJFKHDBTQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  7-氯-4-肼基喹啉 、 3-氯苯甲醛 以 乙醇 为溶剂， 以64%的产率得到7-chloro-N-[(3-chlorophenyl)methylideneamino]quinolin-4-amine
  参考文献：
  名称：

  Synthesis and antitubercular activity of 7-chloro-4-quinolinylhydrazones derivatives

  摘要：

  A series of twenty-one 7-chloro-4-quinolinylhydrazones (3a-u) have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv. The compounds 3f, 3i and 3o were non-cytotoxic and exhibited an important minimum inhibitory concentration (MIC) activity (2.5 mu g/mL), which can be compared with that of the first line drugs, ethambutol (3.12 mu g/mL) and rifampicin (2.0 mu g/mL). These results can be considered an important start point for the rational design of new leads for anti-TB compounds. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.098

文献信息

• Synthesis and antitubercular activity of 7-chloro-4-quinolinylhydrazones derivatives
  作者：André L.P. Candéa、Marcelle de L. Ferreira、Karla C. Pais、Laura N.de F. Cardoso、Carlos R. Kaiser、Maria das Graças M.de O. Henriques、Maria C.S. Lourenço、Flávio A.F.M. Bezerra、Marcus V.N. de Souza

  DOI：10.1016/j.bmcl.2009.09.098

  日期：2009.11

  A series of twenty-one 7-chloro-4-quinolinylhydrazones (3a-u) have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv. The compounds 3f, 3i and 3o were non-cytotoxic and exhibited an important minimum inhibitory concentration (MIC) activity (2.5 mu g/mL), which can be compared with that of the first line drugs, ethambutol (3.12 mu g/mL) and rifampicin (2.0 mu g/mL). These results can be considered an important start point for the rational design of new leads for anti-TB compounds. (C) 2009 Elsevier Ltd. All rights reserved.