(-)-Isofenchon-semicarbazon | 31538-72-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (-)-Isofenchon-semicarbazon
• 英文别名: (-)-Fenchon-semicarbazon；(-)-isofenchone semicarbazone
• CAS: 31538-72-4；63187-82-6
• 化学式: C₁₁H₁₉N₃O
• 分子量: 209.291
• InChiKey: HCFVAVGWCAUKHM-HQJQHLMTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.86
• 重原子数：
  15.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  67.48
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  (4-carboxy-2,2,4-trimethyl-cyclopentyl)-acetic acid 在 barium dihydroxide 作用下， 生成 (-)-Isofenchon-semicarbazon
  参考文献：
  名称：

  46.萜烯化合物。第六部分 （±）-异雄酮的合成

  摘要：

  DOI：

  10.1039/jr9490000197

文献信息

• Gastric acid secretion in L-histidine decarboxylase–deficient mice
  作者：Satoshi Tanaka、Kiyomi Hamada、Noboru Yamada、Yuko Sugita、Shunsuke Tonai、Bèla Hunyady、Miklòs Palkovits、Andras Falus、Takehiko Watanabe、Susumu Okabe、Hiroshi Ohtsu、Atsushi Ichikawa、Andras Nagy

  DOI：10.1053/gast.2002.30312

  日期：2002.1

  Background & Aims: Histamine, gastrin, and acetylcholine are known to be the primary secretagogues of gastric acid secretion, but how the roles are shared among these secretagogues remains to be fully clarified. To evaluate the cooperation between histamine and the other secretagogues, acid secretion responses induced by each secretagogue were measured in L-histidine decarboxylase (HDC)-deficient mice. Methods. Acid secretion was measured by the titration of acid under anesthesia. The expression of selected genes involved in acid secretion was determined by Northern blot and/or immunoblot analysis. Histamine-2 (H-2) receptor binding In the gastric mucosa was investigated using [H-3]tiotidine. Results: HDC-deficient mice showed low basal and high exogenous histamine-stimulated acid secretion. The mutant mice showed hypergastrinemia and did not undergo acid secretion upon treatment with exogenous gastrin. However, carbachol stimulated weak and transient acid secretion in the mutants. The Bmax values for H-2 and the expression of Gsalpha in gastric mucosal membranes were higher in the mutants than,in the wild-type mice. Conclusions: This study confirms the concept that histamine production is essential for gastric acid secretion induced by gastrin, but not for that Induced by carbachol. HDC-deficient mice should be a suitable model for further functional analyses of the correlation between histamine and the other acid secretagogues.
• Schmidt; Todenhoefer, Bericht von Schimmel and Co., 1937, p. 113
  作者：Schmidt、Todenhoefer

  DOI：——

  日期：——