(E)-N-(6,8-ditert-butyl-2-oxochromen-3-yl)-3-[3-(trifluoromethyl)phenyl]prop-2-enamide | 1029092-36-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-N-(6,8-ditert-butyl-2-oxochromen-3-yl)-3-[3-(trifluoromethyl)phenyl]prop-2-enamide
• CAS: 1029092-36-1
• 化学式: C₂₇H₂₈F₃NO₃
• 分子量: 471.519
• InChiKey: REMSYVMXTXJCRH-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  M7-Gly 、 3,5-二叔丁基水杨醛 在 sodium acetate 、 乙酸酐 作用下， 以60%的产率得到(E)-N-(6,8-ditert-butyl-2-oxochromen-3-yl)-3-[3-(trifluoromethyl)phenyl]prop-2-enamide
  参考文献：
  名称：

  Synthesis and antihyperglycemic activity of novel N-acyl-2-arylethylamines and N-acyl-3-coumarylamines

  摘要：

  A series of novel N-acyl-2-arylethylamines and N-acyl-3-coumarylamines were synthesized and evaluated for their anti-hyperglycemic activity. Compounds 3g and 6d exhibited lowering of postprandial plasma glucose by 30.7%, 23.3% in SLM and 25.6%, 25.4% in STZ models respectively which is significant compared to metformin and glybenclamide. Other compounds exhibited moderate to good activity ranging from 19.5% to 32.8% in SLM and 3.26% to 25.4% in STZ models. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.03.003