ciprofloxacin carbon | 952653-67-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ciprofloxacin carbon
• 英文别名: Methylciprofloxacin；1-cyclopropyl-6-fluoro-2-methyl-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
• CAS: 952653-67-7
• 化学式: C₁₈H₂₀FN₃O₃
• 分子量: 345.374
• InChiKey: VXLLKJNPBMNVMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  72.9
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1-cyclopropyl-6-fluoro-2-methyl-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 在 sodium hydroxide 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 12.0h， 以54%的产率得到ciprofloxacin carbon
  参考文献：
  名称：

  Identification, biological activity, and mechanism of the anti-ischemic quinolone analog

  摘要：

  The quinolone analog SQ-4004 has been identified as a potentially excellent anti-ischemic agent, which exhibited highly potent efficacy in reducing infarct volume size in vivo rat MCAO model (32.1% at 0.01 mg/kg) and potent cardioprotective effect at myocardial infarction in vivo model (26.6% at 0.01 mg/kg) while it exhibited highly reduced anti-bacterial activity. The mechanistic study revealed that the anti-ischemic activity might exert via an anti-apoptotic pathway, which implies its therapeutic uses against the ischemic cell injuries including ischemic stroke and ischemic heart disease. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.07.009

文献信息

• Identification, biological activity, and mechanism of the anti-ischemic quinolone analog
  作者：Chan-Hee Park、Jongwon Lee、Hwi Young Jung、Min Ji Kim、Sun Ha Lim、Hyung Tae Yeo、Eung Chil Choi、Eun Jeong Yoon、Kyu Won Kim、Jong Ho Cha、Seok-Ho Kim、Dong-Jo Chang、Do-Yeon Kwon、Funan Li、Young-Ger Suh

  DOI：10.1016/j.bmc.2007.07.009

  日期：2007.10

  The quinolone analog SQ-4004 has been identified as a potentially excellent anti-ischemic agent, which exhibited highly potent efficacy in reducing infarct volume size in vivo rat MCAO model (32.1% at 0.01 mg/kg) and potent cardioprotective effect at myocardial infarction in vivo model (26.6% at 0.01 mg/kg) while it exhibited highly reduced anti-bacterial activity. The mechanistic study revealed that the anti-ischemic activity might exert via an anti-apoptotic pathway, which implies its therapeutic uses against the ischemic cell injuries including ischemic stroke and ischemic heart disease. (c) 2007 Elsevier Ltd. All rights reserved.