16-[2,6-dimethoxy-4-[(E)-2-(4-methoxyphenyl)ethenyl]phenyl]hexadecan-1-ol | 947736-03-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 16-[2,6-dimethoxy-4-[(E)-2-(4-methoxyphenyl)ethenyl]phenyl]hexadecan-1-ol
• CAS: 947736-03-0
• 化学式: C₃₃H₅₀O₄
• 分子量: 510.758
• InChiKey: JRKIIXKBNHYNIC-FMQUCBEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.9
• 重原子数：
  37
• 可旋转键数：
  21
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  16-[2,6-dimethoxy-4-[(E)-2-(4-methoxyphenyl)ethenyl]phenyl]hexadecan-1-ol 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Dual bioactivity of resveratrol fatty alcohols: Differentiation of neural stem cells and modulation of neuroinflammation

  摘要：

  The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and (omega-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.05.037
• 作为产物：
  描述：

  4-甲氧基苄醇 在 盐酸 、 氢碘酸 、 sodium methylate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 生成 16-[2,6-dimethoxy-4-[(E)-2-(4-methoxyphenyl)ethenyl]phenyl]hexadecan-1-ol
  参考文献：
  名称：

  Dual bioactivity of resveratrol fatty alcohols: Differentiation of neural stem cells and modulation of neuroinflammation

  摘要：

  The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and (omega-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.05.037

文献信息

• Dual bioactivity of resveratrol fatty alcohols: Differentiation of neural stem cells and modulation of neuroinflammation
  作者：Frédérique Hauss、Jiawei Liu、Alessandro Michelucci、Djalil Coowar、Eleonora Morga、Paul Heuschling、Bang Luu

  DOI：10.1016/j.bmcl.2007.05.037

  日期：2007.8

  The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and (omega-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies. (c) 2007 Elsevier Ltd. All rights reserved.