| 1477511-11-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1477511-11-7
• 化学式: C₄₅H₄₀NO₁₁P
• 分子量: 801.786
• InChiKey: XAPRXVSMEUENFJ-MFAOBIFUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.72
• 重原子数：
  58.0
• 可旋转键数：
  12.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  136.13
• 氢给体数：
  0.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  、 phenyl 2,3,4-tri-O-benzoyl-1-thio-α-D-mannopyranoside 在 N-氰甲基吡咯烷鎓三氟甲烷磺酸盐 作用下， 以 乙腈 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  Stereoselective Synthesis of P-Modified α-Glycosyl Phosphates by the Oxazaphospholidine Approach

  摘要：

  alpha-Glycosyl phosphate derivatives are widely known as constituents of biomolecules. To date, several types of non-natural alpha-glycosyl phosphates including "P-modified analogs" have been synthesized to investigate their characteristics. Herein a new approach to the stereoselective modification of the intersugar phosphorus atom in alpha-glycosyl phosphates by use of the oxazaphospholidine method is presented. Via this approach, the dimers of alpha-glycosyl phosphorothioates and alpha-glycosyl boranophosphates were obtained efficiently and stereoselectively.

  DOI：

  10.1021/ol402785h
• 作为产物：
  描述：

  (S)-α-<(R)-pyrrolidin-2-yl>benzyl alcohol 在 三乙胺 、 三氯化磷 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  Stereoselective Synthesis of P-Modified α-Glycosyl Phosphates by the Oxazaphospholidine Approach

  摘要：

  alpha-Glycosyl phosphate derivatives are widely known as constituents of biomolecules. To date, several types of non-natural alpha-glycosyl phosphates including "P-modified analogs" have been synthesized to investigate their characteristics. Herein a new approach to the stereoselective modification of the intersugar phosphorus atom in alpha-glycosyl phosphates by use of the oxazaphospholidine method is presented. Via this approach, the dimers of alpha-glycosyl phosphorothioates and alpha-glycosyl boranophosphates were obtained efficiently and stereoselectively.

  DOI：

  10.1021/ol402785h