| 1419374-93-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1419374-93-8
• 化学式: C₁₁H₁₂O₂S
• 分子量: 208.281
• InChiKey: OIJBKAYFHIKHBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.43
• 重原子数：
  14.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  34.14
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  在 sodium hydroxide 作用下， 以 乙醚 、 水 为溶剂， 反应 4.0h， 生成 2-(prop-2-yn-1-yl) cyclohex-2-enone
  参考文献：
  名称：

  A Bifunctional Lewis Acid Induced Cascade Cyclization to the Tricyclic Core of ent-Kaurenoids and Its Application to the Formal Synthesis of (±)-Platensimycin

  摘要：

  A mild and efficient bifunctional Lewis acid induced cascade cyclization reaction has been developed for construction of the tricyclic core of ent-kaurenolds. With ZnBr2 as the bifunctional Lewis acid, a series of substituted enones and dienes underwent cascade cyclization smoothly at room temperature and provided the tricyclic products in one pot with good yields (75-91%) and high diastereoselectivity. The cyclized product has been successfully employed for the formal synthesis of (+/-)-platenslmycln.

  DOI：

  10.1021/ol3033412
• 作为产物：
  描述：

  2-环己烯-1-酮 在 sodium methylate 、 potassium carbonate 作用下， 以 甲醇 、 丙酮 为溶剂， 反应 14.08h， 生成
  参考文献：
  名称：

  A Bifunctional Lewis Acid Induced Cascade Cyclization to the Tricyclic Core of ent-Kaurenoids and Its Application to the Formal Synthesis of (±)-Platensimycin

  摘要：

  A mild and efficient bifunctional Lewis acid induced cascade cyclization reaction has been developed for construction of the tricyclic core of ent-kaurenolds. With ZnBr2 as the bifunctional Lewis acid, a series of substituted enones and dienes underwent cascade cyclization smoothly at room temperature and provided the tricyclic products in one pot with good yields (75-91%) and high diastereoselectivity. The cyclized product has been successfully employed for the formal synthesis of (+/-)-platenslmycln.

  DOI：

  10.1021/ol3033412