4-Dimethylamino-chinaldin | 21875-62-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-Dimethylamino-chinaldin
• 英文别名: N,N,2-trimethylquinolin-4-amine
• CAS: 21875-62-7
• 化学式: C₁₂H₁₄N₂
• 分子量: 186.257
• InChiKey: RCKNDOZXXYZFQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Dimethylamino-chinaldin 在 碘 、 对甲苯磺酸 作用下， 以 二甲基亚砜 为溶剂， 130.0 ℃ 、101.33 kPa 条件下， 反应 16.0h， 以60%的产率得到4-(dimethylamino)quinoline-2-carbaldehyde
  参考文献：
  名称：

  杂芳族甲烷的无金属和自由基的好氧氧化：杂芳族醛的有效合成

  摘要：

  通过在I 2 / DMSO / O 2催化系统中对甲基进行好氧氧化，开发了杂芳醛的无金属和无自由基合成方法。在反应条件下，各种官能团如甲氧基，醛基，酯基，硝基，酰胺基和卤素（F，Cl，Br）基团均具有良好的耐受性。诸如氯霉素衍生物和罂粟碱的生物活性化合物也被氧化成相应的醛和酮。该反应提供了制备有价值的杂芳族醛的有效方法。

  DOI：

  10.1039/c9ob00490d

文献信息

• CHEMICAL DERIVATIVES AND THEIR APPLICATION AS ANTITELOMERASE AGENTS
  申请人：MAILLIET Patrick

  公开号：US20090226411A1

  公开（公告）日：2009-09-10

  The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which is quite specific. It also relates to novel chemical compounds as well as their therapeutic application in humans.

  本发明涉及癌症治疗以及具有相当特异作用机制的新型抗癌剂。它还涉及新型化学化合物以及它们在人类治疗中的治疗应用。
• Shelf life mass polymerizable polycycloolefin compositions as optical materials
  申请人：PROMERUS, LLC

  公开号：US11230566B2

  公开（公告）日：2022-01-25

  Embodiments in accordance with the present invention encompass compositions encompassing a latent organo-ruthenium compound and a pyridine compound along with one or more monomers which undergo ring open metathesis polymerization (ROMP) when said composition is exposed to suitable actinic radiation to form a substantially transparent film. Surprisingly, the compositions are very stable at ambient conditions to temperatures up to 80° C. for several days and undergo mass polymerization when subject only to actinic radiation. Accordingly, compositions of this invention are useful in various opto-electronic applications, including as 3D printing materials, coatings, encapsulants, fillers, leveling agents, among others.

  根据本发明的实施方案，本发明的组合物包括一种潜在的有机钌化合物和一种吡啶化合物，以及一种或多种单体，当所述组合物暴露于适当的光辐射下形成基本透明的薄膜时，这些单体会发生开环偏聚（ROMP）。令人惊奇的是，这种组合物在环境条件下非常稳定，温度最高可达 80 摄氏度，可持续数天，而且仅在光辐射下就会发生大规模聚合。因此，本发明的组合物可用于各种光电子应用，包括用作 3D 打印材料、涂层、封装剂、填料、流平剂等。
• Long shelf life stable photoactive mass polymerizable polycycloolefin compositions as optical materials
  申请人：PROMERUS, LLC

  公开号：US11535702B2

  公开（公告）日：2022-12-27

  Embodiments in accordance with the present invention encompass compositions encompassing a latent organo-ruthenium compound, a photosensitizer and one or more monomers which undergo ring open metathesis polymerization (ROMP) when said composition is exposed to suitable actinic radiation to form a substantially transparent film or a three dimensional object. Surprisingly, the compositions are very stable at ambient conditions to temperatures up to 80° C. for several weeks and undergo mass polymerization only when subjected to actinic radiation under inert atmosphere such as for example a blanket of nitrogen. Accordingly, compositions of this invention are useful in various opto-electronic applications, including as 3D printing materials, coatings, encapsulants, fillers, leveling agents, among others.

  根据本发明的实施方案，本发明的组合物包括一种潜在的有机钌化合物、一种光敏剂和一种或多种单体，当所述组合物暴露在适当的光辐射下时，这些单体会发生开环偏聚聚合反应（ROMP），从而形成基本透明的薄膜或三维物体。令人惊奇的是，这种组合物在环境条件下非常稳定，温度最高可达 80 摄氏度，可持续数周，并且只有在惰性气氛（例如氮气毯）下接受光辐射时才会发生大规模聚合。因此，本发明的组合物可用于各种光电子应用，包括用作 3D 打印材料、涂层、封装材料、填料、流平剂等。
• 1,1-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLOPROTEASE AND TNF-$g(a)
  申请人：Bristol-Myers Squibb Pharma Company

  公开号：EP1355901A2

  公开（公告）日：2003-10-29
• STABLE POLYCYCLOOLEFIN POLYMER AND INORGANIC NANOPARTICLE COMPOSITIONS AS OPTICAL MATERIALS
  申请人：PROMERUS, LLC

  公开号：US20210024685A1

  公开（公告）日：2021-01-28

  Embodiments in accordance with the present invention encompass compositions encompassing a latent organo-ruthenium catalyst, an organo-ruthenium compound and a pyridine compound along with one or more monomers which undergo ring open metathesis polymerization (ROMP) when said composition is heated to a temperature from 80° C. to 150° C. or higher to form a substantially transparent film. Alternatively the compositions of this invention also undergo polymerization when subjected to suitable radiation. The monomers employed therein have a range of refractive index from 1.4 to 1.6 and thus these compositions can be tailored to form transparent films of varied refractive indices. The compositions of this invention further comprises inorganic nanoparticles which form transparent films and further increases the refractive indices of the compositions. Accordingly, compositions of this invention are useful in various opto-electronic applications, including as coatings, encapsulants, fillers, leveling agents, among others.