11-cis-5,6-Dihydro-retinal | 26563-61-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 11-cis-5,6-Dihydro-retinal
• 英文别名: (2E,4Z,6E,8E)-3,7-dimethyl-9-(2,2,6-trimethylcyclohexyl)nona-2,4,6,8-tetraenal
• CAS: 26563-61-1
• 化学式: C₂₀H₃₀O
• 分子量: 286.458
• InChiKey: UREHIXRTGAZOND-IOUUIBBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Management of Ophthalmologic Disorders, Including Macular Degeneration
  申请人：Rando Robert R.

  公开号：US20090227649A1

  公开（公告）日：2009-09-10

  A drug may be used in the preparation of a medicament for the treatment or prevention of an ophthalmologic disorder, wherein the drug inhibits, antagonizes, or short-circuits the visual cycle at a step of the visual cycle that occurs outside a disc of a rod photoreceptor cell.

  一种药物可以用于制备治疗或预防眼科疾病的药物，其中该药物抑制、拮抗或短路视觉周期，该视觉周期发生在杆状感光细胞的盘外步骤。
• METHODS FOR ASSESSING A PHYSIOLOGICAL STATE OF A MAMMALIAN RETINA
  申请人：Imanishi Yoshikazu

  公开号：US20100262016A1

  公开（公告）日：2010-10-14

  In one aspect the present invention provides methods for assessing a physiological state of a mammalian retina in vivo, the methods of this aspect of the invention each include the steps of (a) irradiating a portion of a mammalian retina, in vivo, with light having a wavelength in the range of from 600 nm to 1000 nm at an intensity sufficient to stimulate two-photon-induced fluorescence in the retina; and (b) assessing a physiological state of the retina by analyzing the fluorescence.