4-methyl-3-(3-(3-(((R)-1-(naphthalen-1-yl)ethyl)amino)propyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride | 1574000-08-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 4-methyl-3-(3-(3-(((R)-1-(naphthalen-1-yl)ethyl)amino)propyl)-1,2,3,4-tetrahydronaphthalen-1-yl)benzoic acid hydrochloride
• 英文别名: 4-methyl-3-[3-[3-[[(1R)-1-naphthalen-1-ylethyl]amino]propyl]-1,2,3,4-tetrahydronaphthalen-1-yl]benzoic acid;hydrochloride
• CAS: 1574000-08-0
• 化学式: C₃₃H₃₅NO₂*ClH
• 分子量: 514.107
• InChiKey: RARSAXYIRCPBEC-NBRWVONZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.09
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.3
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS<br/>[FR] COMPOSÉS D'ARYLALKYLAMINE JOUANT LE RÔLE DE MODULATEURS DES RÉCEPTEURS SENSIBLES AU CALCIUM
  申请人：LUPIN LTD

  公开号：WO2014033604A1

  公开（公告）日：2014-03-06

  The present invention provides arylalkylamine compounds as calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention. (Formula I)

  本发明提供了作为钙感应受体调节剂（CaSR）的芳烷基胺化合物。特别是，本发明的化合物可用于治疗、管理或减轻与调节钙感应受体（CaSR）相关疾病、障碍、综合征和/或症状的严重性。本发明还提供了包含这些化合物的药物组合物，以及用于治疗、管理或减轻与调节CaSR相关的疾病、障碍、综合征和/或症状的方法。本发明还涉及制备本发明化合物的方法。（公式I）
• ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS
  申请人：Lupin Limited

  公开号：US20150239827A1

  公开（公告）日：2015-08-27

  The present invention provides arylalkylamine compounds as calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention. (Formula I)

  本发明提供了芳基烷基胺化合物作为钙感受器调节剂（CaSR）。特别地，本文所描述的化合物可用于治疗、管理和/或减轻与钙感受器调节剂（CaSR）调节相关的疾病、疾病、综合症和/或病况的严重程度。本发明还提供了它们的药物组合物和治疗、管理和/或减轻与CaSR调节相关的疾病、疾病、综合症和/或病况的严重程度的方法。本发明还涉及制备本发明化合物的方法。（公式I）
• US9227919B2
  申请人：——

  公开号：US9227919B2

  公开（公告）日：2016-01-05
• US9598371B2
  申请人：——

  公开号：US9598371B2

  公开（公告）日：2017-03-21