α-methyl-4-isobutyl-phenylacetic acid | 64451-67-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: α-methyl-4-isobutyl-phenylacetic acid
• 英文别名: α-methyl-p-isobutylphenylacetic acid；2-[4-(3-Methylbutan-2-yl)phenyl]acetic acid
• CAS: 64451-67-8
• 化学式: C₁₃H₁₈O₂
• 分子量: 206.285
• InChiKey: KJBZJVQFKVCPED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• COMPOSITION FOR FORMING UPPER FILM AND METHOD FOR FORMING PHOTORESIST PATTERN
  申请人：JSR Corporation

  公开号：EP1950610A1

  公开（公告）日：2008-07-30

  An upper layer-forming composition formed on a photoresist while causing almost no intermixing with the photoresist film and a photoresist patterning method are provided. The upper layer-forming composition is stably maintained without being eluted in a medium such as water during liquid immersion lithography and is easily dissolved in an alkaline developer. The upper layer-forming composition covers a photoresist film for forming a pattern by exposure to radiation. The composition comprises a resin dissolvable in a developer for the photoresist film and a solvent in which the resin is dissolved. The solvent has a viscosity of less than 5.2 x 10-3 Pa·s at 20°C. In addition, the solvent does not cause intermixing of the photoresist film and the upper layer-forming composition. The solvent contains an ether or a hydrocarbon.

  本发明提供了一种在光刻胶上形成的上层形成组合物，同时几乎不会造成与光刻胶膜的混合，并提供了一种光刻胶图案化方法。在液浸光刻过程中，上层形成组合物可稳定地保持在水等介质中而不会被洗脱，并且很容易溶解在碱性显影剂中。上层形成组合物覆盖在光刻胶膜上，通过辐射形成图案。该组合物包括一种可溶解于光刻胶膜显影剂中的树脂和一种可溶解树脂的溶剂。溶剂在 20°C 时的粘度小于 5.2 x 10-3 Pa-s。此外，该溶剂不会造成光刻胶膜和上层形成组合物的混合。溶剂含有醚或烃。
• Coated sensors, and corresponding systems and methods
  申请人：Cell and Molecular Tissue Engineering, LLC

  公开号：US10130288B2

  公开（公告）日：2018-11-20

  Disclosed herein are sensors with a layer of dehydrated modified basement membrane preparation formed thereon. The basement membrane has been modified before dehydration of remove low molecular weight components. In some embodiments, the basement membrane is crosslinked. Methods of making and using the products also are disclosed.

  本文介绍的传感器上有一层脱水改性基底膜制剂。基底膜在脱水去除低分子量成分之前已被改性。在某些实施例中，基底膜是交联的。此外，还公开了制造和使用这些产品的方法。
• Coated surgical mesh, and corresponding systems and methods
  申请人：Cell and Molecular Tissue Engineering, LLC

  公开号：US10405961B2

  公开（公告）日：2019-09-10

  Disclosed herein are medical products, including a surgical mesh, with a layer of dehydrated modified basement membrane preparation formed thereon. The basement membrane has been modified before dehydration of remove low molecular weight components. In some embodiments, the basement membrane is crosslinked. Methods of making and using the products also are disclosed.

  本文所公开的是医疗产品，包括一种手术网，其上形成了一层脱水改性基底膜制剂。基底膜在脱水去除低分子量成分之前已被改性。在某些实施例中，基底膜是交联的。此外，还公开了制造和使用这些产品的方法。
• Apparatus and method for control of tissue/implant interactions
  申请人：——

  公开号：US20030099682A1

  公开（公告）日：2003-05-29

  A tissue/implant interface, comprising an implant and a bioactive polymer layer adjacent at least a portion of the outer surface of the implant, wherein the polymer layer contains at least one tissue response modifier covalently attached to the polymer layer or entrapped within the polymer layer in a quantity effective to control the tissue response at the site of implantation. Preferably, the at least one tissue response modifier controls inflammation, fibrosis, and/or neovascularization. Exemplary tissue response modifiers include, but are not limited to, steroidal and non-steroidal anti-inflammatory agents, anti-fibrotic agents, anti-proliferative agents, cytokines, cytokine inhibitors, neutralizing antibodies, adhesive ligands, and combinations thereof. Use of the various combinations of tissue response modifiers with bioactive polymers provides a simple, flexible and effective means to control the implant/tissue interphase, improving implant lifetime and function.

  一种组织/植入物界面，包括植入物和与植入物外表面至少一部分相邻的生物活性聚合物层，其中聚合物层含有至少一种共价连接到聚合物层或夹带在聚合物层中的组织反应调节剂，其数量可有效控制植入部位的组织反应。最好，至少一种组织反应调节剂能控制炎症、纤维化和/或新生血管。示例性组织反应调节剂包括但不限于类固醇和非类固醇抗炎剂、抗纤维化剂、抗增殖剂、细胞因子、细胞因子抑制剂、中和抗体、粘附配体及其组合。将各种组织反应调节剂与生物活性聚合物结合使用，可提供一种简单、灵活而有效的方法来控制植入物/组织间的相位，从而提高植入物的使用寿命和功能。
• Low profile combination device for gastrostomy or jejunostomy applications having anti-granuloma formation characteristics
  申请人：——

  公开号：US20040024363A1

  公开（公告）日：2004-02-05

  A combination device for gastrostomy or jejunostomy usage having a retaining member, an elongated member having a gastrostomy lumen and a jejustomy lumen, and an inflatable balloon mounted on the elongated member. The retaining member is of a low profile and is arranged to be located on the skin adjacent a stoma in the abdominal wall through which the elongated member extends. The balloon seals the stoma about the elongated member. The retaining member includes at least one access port to communicate with respective ones of the lumens. The device, related compositions, and processes can prevent and/or treat granulomas.

  一种用于胃造口术或空肠造口术的组合装置，具有一个固定部件、一个具有胃造口术管腔和空肠造口术管腔的细长部件，以及一个安装在细长部件上的充气球囊。固定部件外形低矮，安装在细长部件穿过的腹壁造口附近的皮肤上。气球将造口与细长部件密封在一起。固定部件包括至少一个通孔，用于与各自的管腔相通。该装置、相关组合物和工艺可预防和/或治疗肉芽肿。