| 1582775-72-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1582775-72-1
• 化学式: C₄₆H₇₀F₇N₃O₃₉S₂
• 分子量: 1486.18
• InChiKey: MGNXUOFPKAUPSW-JIPICLNHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -10.24
• 重原子数：
  97.0
• 可旋转键数：
  27.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  656.78
• 氢给体数：
  21.0
• 氢受体数：
  34.0

反应信息

• 作为反应物：
  描述：

  在 heparan sulfate 6-O-sulfotransferase isoform-1 、 heparan sulfate 6-O-sulfotransferase isoform-3 、 6-氨基-9-[3-羟基-5-[(羟基-磺基氧基-磷酰)氧基甲基]-4-膦酰氧基-四氢呋喃-2-基]-嘌呤 作用下， 以 aq. buffer 为溶剂， 以94%的产率得到
  参考文献：
  名称：

  Fluorous-Assisted Chemoenzymatic Synthesis of Heparan Sulfate Oligosaccharides

  摘要：

  The chemoenzymatic synthesis of heparan sulfate tetrasaccharide (1) and hexasaccharide (2) with a fluorous tag. attached at the reducing end is reported. The fluorous tert-butyl dicarbonate ((F)Boc) tag did not interfere with enzymatic recognition for both elongation and specific sulfation, and flash purification was performed by standard fluorous solid-phase extraction (FSPE). Based on an (F)Boc attached disaccharide as acceptor, a series of partial N-sulfated, 6-O-sulfated heparan sulfate. oligosaccharides were successfully synthesized employing fluorous techniques.

  DOI：

  10.1021/ol500738g
• 作为产物：
  描述：

  在 三甲基氨基磺酸 、 sodium carbonate 作用下， 以 水 为溶剂， 以0.17 mg的产率得到
  参考文献：
  名称：

  Fluorous-Assisted Chemoenzymatic Synthesis of Heparan Sulfate Oligosaccharides

  摘要：

  The chemoenzymatic synthesis of heparan sulfate tetrasaccharide (1) and hexasaccharide (2) with a fluorous tag. attached at the reducing end is reported. The fluorous tert-butyl dicarbonate ((F)Boc) tag did not interfere with enzymatic recognition for both elongation and specific sulfation, and flash purification was performed by standard fluorous solid-phase extraction (FSPE). Based on an (F)Boc attached disaccharide as acceptor, a series of partial N-sulfated, 6-O-sulfated heparan sulfate. oligosaccharides were successfully synthesized employing fluorous techniques.

  DOI：

  10.1021/ol500738g