10-benzyl-3,4-dihydroacridine-1,9(2H,10H)-dione | 143261-94-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 10-benzyl-3,4-dihydroacridine-1,9(2H,10H)-dione
• 英文别名: 10-benzyl-3,4-dihydro-2H-acridine-1,9-dione
• CAS: 143261-94-3
• 化学式: C₂₀H₁₇NO₂
• 分子量: 303.36
• InChiKey: UMNXGVUVJGIKMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.57
• 重原子数：
  23.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  39.07
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  10-benzyl-3,4-dihydroacridine-1,9(2H,10H)-dione 在 sodium azide 、 硫酸 作用下， 以 氯仿 为溶剂， 以60%的产率得到4,5-dihydro-3H-isoxazolo<3,4,5-kl>acridine
  参考文献：
  名称：

  Synthesis of 1,2,3,4-Tetrahydroacridine and 5,6,7,8-Tetrahydroquinoline Derivatives as Potential Acetylcholinesterase Inhibitors

  摘要：

  This paper describes the synthesis of 1,3,4,5-tetrahydropyrazolo[3,4,5-kl]acridine (2) and 11-amino-1,3,4,5-tetrahydro-azepino[3,2-b]quinolin-2-one (3) obtained by Schmidt reaction of 9-amino-3,4-dihydroacridin-1(2H)-one (1) and the preparation of 4,5-dihydro-3H-isoxazolo[3,4,5-kl]acridine (7) obtained in the same manner starting f rom 3, 4-dihydroacridine-1, 9 (2H, 10H) -dione (6) . The corresponding pyrazolo[3,4,5-de]quinoline (20) and isoxazolo[5,4,3-de]quinoline (18) are also reported. The compounds have been prepared with the aim of studying their possible activity as acetylcholinesterase inhibitors.

  DOI：

  10.3987/com-92-5977
• 作为产物：
  描述：

  溴甲苯 、 1,2,3,4,9,10-hexahydroacridine-1,9-dione 在 sodium hydroxide 、 苄基三甲基氯化铵 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以40%的产率得到10-benzyl-3,4-dihydroacridine-1,9(2H,10H)-dione
  参考文献：
  名称：

  Synthesis of 1,2,3,4-Tetrahydroacridine and 5,6,7,8-Tetrahydroquinoline Derivatives as Potential Acetylcholinesterase Inhibitors

  摘要：

  This paper describes the synthesis of 1,3,4,5-tetrahydropyrazolo[3,4,5-kl]acridine (2) and 11-amino-1,3,4,5-tetrahydro-azepino[3,2-b]quinolin-2-one (3) obtained by Schmidt reaction of 9-amino-3,4-dihydroacridin-1(2H)-one (1) and the preparation of 4,5-dihydro-3H-isoxazolo[3,4,5-kl]acridine (7) obtained in the same manner starting f rom 3, 4-dihydroacridine-1, 9 (2H, 10H) -dione (6) . The corresponding pyrazolo[3,4,5-de]quinoline (20) and isoxazolo[5,4,3-de]quinoline (18) are also reported. The compounds have been prepared with the aim of studying their possible activity as acetylcholinesterase inhibitors.

  DOI：

  10.3987/com-92-5977