(S)-3-[Bis-(3-chloro-benzyloxy)-phosphoryloxy]-2-tert-butoxycarbonylamino-propionic acid 2-oxo-2-phenyl-ethyl ester | 188478-24-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-3-[Bis-(3-chloro-benzyloxy)-phosphoryloxy]-2-tert-butoxycarbonylamino-propionic acid 2-oxo-2-phenyl-ethyl ester
• CAS: 188478-24-2
• 化学式: C₃₀H₃₂Cl₂NO₉P
• 分子量: 652.465
• InChiKey: WOYQFSOORKNLQV-SANMLTNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.17
• 重原子数：
  43.0
• 可旋转键数：
  14.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  126.46
• 氢给体数：
  1.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  (S)-3-[Bis-(3-chloro-benzyloxy)-phosphoryloxy]-2-tert-butoxycarbonylamino-propionic acid 2-oxo-2-phenyl-ethyl ester 在 溶剂黄146 、 锌 作用下， 反应 1.0h， 生成 (S)-3-[Bis-(3-chloro-benzyloxy)-phosphoryloxy]-2-tert-butoxycarbonylamino-propionic acid
  参考文献：
  名称：

  Synthetic study of phosphopeptides related to heat shock protein HSP27

  摘要：

  Two kinds of phosphoserine-containing peptides related to HSP27 were synthesized by the Boc- or Fmoc-mode solid-phase method based on prephosphorylation strategy. In the case of the Boc strategy, the O-phosphono group of the phosphoserine residue was protected with the cyclopentyl or cyclohexyl group. On the other hand, N-alpha-Fmoc-O-[(benzyloxy)-hydroxyphosphinyl]serine was employed in case of the Fmoc strategy. Consequently, it has become feasible to utilize conventional solid-phase methods for synthesizing any phosphopeptides which are required to elucidate biochemical significance of protein phosphorylation. Copyright (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(96)00208-8
• 作为产物：
  描述：

  3-氯苯甲醇 在 四氮唑 、 三乙胺 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 为溶剂， 反应 4.67h， 生成 (S)-3-[Bis-(3-chloro-benzyloxy)-phosphoryloxy]-2-tert-butoxycarbonylamino-propionic acid 2-oxo-2-phenyl-ethyl ester
  参考文献：
  名称：

  Synthetic study of phosphopeptides related to heat shock protein HSP27

  摘要：

  Two kinds of phosphoserine-containing peptides related to HSP27 were synthesized by the Boc- or Fmoc-mode solid-phase method based on prephosphorylation strategy. In the case of the Boc strategy, the O-phosphono group of the phosphoserine residue was protected with the cyclopentyl or cyclohexyl group. On the other hand, N-alpha-Fmoc-O-[(benzyloxy)-hydroxyphosphinyl]serine was employed in case of the Fmoc strategy. Consequently, it has become feasible to utilize conventional solid-phase methods for synthesizing any phosphopeptides which are required to elucidate biochemical significance of protein phosphorylation. Copyright (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(96)00208-8