| 13463-98-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• CAS: 13463-98-4
• 化学式: C20H30CaO2
• 分子量: 342.5
• InChiKey: CYGYSXBYVMMYFC-XTICBAGASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.83
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Sulphonated dehydrogenated sylvate, the preparation and use
  申请人：——

  公开号：US20040162341A1

  公开（公告）日：2004-08-19

  This invention relates to salts of sulfodehydroabietic acid with bismuth or zinc, a kind of new salt useful in treating digestive canal ulcer, acute & chronic gastritis, and erosive gastritis etc., as well as its preparation and use. Said salts can be represented by formula (1), wherein R is Bi(OH) ++ or Zn ++ , 2Bio + , 1/2ZnH, n=0-10. The preparation method comprises following steps: (a) sequentially treating the industrial abietic acid calcium salt with acid, base and extracting with organic solvent to give abietic acid with less isomer; (b) reacting said abietic acid with Pd/C to provide dehydroabietic acid, then converting it to pure sulphonic product, namely sulfodehydroabietic acid, via sulphonation and recrystallization; (c) by use of neutralization or salt displacement reaction to convert the sulphonic product of zinc or bismuth salts of sulfodehydroabietic acid. The resultant salts can used to prepare medicine for treating digestive canal ulcer and gastritis. 1

  本发明涉及硫代脱松香酸与铋或锌的盐，这是一种新的盐，可用于治疗消化道溃疡、急慢性胃炎、侵蚀性胃炎等疾病，以及其制备和使用。所述盐可以用公式（1）表示，其中R为Bi(OH)2+或Zn2+，2Bio+，1/2ZnH，n=0-10。制备方法包括以下步骤：(a)顺序处理工业松香酸钙盐，用酸、碱依次处理，并用有机溶剂提取，得到具有较少异构体的松香酸；(b)将所述松香酸与Pd/C反应，提供脱氢松香酸，然后通过磺化和重结晶将其转化为纯硫酸盐产物，即硫代脱松香酸；(c)通过中和或盐置换反应，将硫代脱松香酸的锌或铋盐的硫酸盐产物转化为盐。所得盐可用于制备治疗消化道溃疡和胃炎的药物。
• US7015343B2
  申请人：——

  公开号：US7015343B2

  公开（公告）日：2006-03-21