| 1194045-69-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• CAS: 1194045-69-6
• 化学式: C₃₄H₄₂ClN₃O₅
• 分子量: 608.178
• InChiKey: LKUXZRBKSCPUGM-NFAWANINSA-N

反应信息

• 作为反应物：
  描述：

  在 10% palladium on carbon 、 氢气 作用下， 以 乙醇 为溶剂， 生成 4-amino-5-chloro-N-((3S,4R)-1-(((1S,2S)-2-hydroxy-2-(3-hydroxyphenyl)cyclohexyl)methyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide
  参考文献：
  名称：

  μ-Opioid/5-HT4 dual pharmacologically active agents—Efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I)

  摘要：

  Novel compounds were prepared that united the pharmacologies of the mu-opioid tramadol with the 5-HT4 agonists metoclopramide and norcisapride. The synthesis, chiral separation and in vitro activity of the new compounds is described. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.08.016
• 作为产物：
  描述：

  在 AD column 作用下， 以 ipa 、 正己烷 、 二乙胺 为溶剂， 生成 、 、 、
  参考文献：
  名称：

  μ-Opioid/5-HT4 dual pharmacologically active agents—Efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I)

  摘要：

  Novel compounds were prepared that united the pharmacologies of the mu-opioid tramadol with the 5-HT4 agonists metoclopramide and norcisapride. The synthesis, chiral separation and in vitro activity of the new compounds is described. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.08.016