4-(1-methylethyl)-N-3-pyrrolidinylbenzamide | 1144524-69-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 4-(1-methylethyl)-N-3-pyrrolidinylbenzamide
• 英文别名: 4-propan-2-yl-N-pyrrolidin-3-ylbenzamide
• CAS: 1144524-69-5
• 化学式: C₁₄H₂₀N₂O
• mdl: MFCD12085757
• 分子量: 232.326
• InChiKey: DZFLTYRTZBQEOD-UHFFFAOYSA-N

物化性质

• 沸点：
  396.8±42.0 °C(Predicted)
• 密度：
  1.07±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS<br/>[FR] DÉRIVÉS D'INDOLE UTILES COMME ACTIVATEURS DE PPAR
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2009047240A1

  公开（公告）日：2009-04-16

  There is provided according to the invention novel compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: (I) useful as PPAR activators.

  根据本发明提供了化合物的新颖结构式(I)或其药学上可接受的盐或溶剂：(I)，可用作PPAR激活剂。
• IRAK4 inhibitor and use thereof
  申请人：BEIJING HANMI PHARMACEUTICAL CO., LTD.

  公开号：US10988482B2

  公开（公告）日：2021-04-27

  The present invention relates to a compound inhibiting the activity of an IRAK4 kinase, a pharmaceutical composition thereof, a use thereof in preparing drugs, a method in which same is used for inhibiting the activity of the IRAK4 kinase and a method in which same is used for treating and/or preventing IRAK4 kinase mediated diseases or conditions in mammals (particularly humans). The compound has a structural formula I.

  本发明涉及一种抑制IRAK4激酶活性的化合物、其药物组合物、其在制备药物中的用途、其用于抑制IRAK4激酶活性的方法以及其用于治疗和/或预防哺乳动物（特别是人类）中IRAK4激酶介导的疾病或病症的方法。该化合物具有结构式 I。
• IRAK4 INHIBITOR AND USE THEREOF
  申请人：BEIJING HANMI PHARMACEUTICAL CO., LTD.

  公开号：US20200062775A1

  公开（公告）日：2020-02-27

  The present invention relates to a compound inhibiting the activity of an IRAK4 kinase, a pharmaceutical composition thereof, a use thereof in preparing drugs, a method in which same is used for inhibiting the activity of the IRAK4 kinase and a method in which same is used for treating and/or preventing IRAK4 kinase mediated diseases or conditions in mammals (particularly humans). The compound has a structural formula I.