2-[methyl(15-phenylpentadecyl)amino]-2-oxoethyl (5Z)-7-{(1R,2R,3R,5R)-5-chloro-2-[(1E,4S)-4-(1-ethylcyclobutyl)-4-hydroxy-1-buten-1-yl]-3-hydroxycyclopentyl}-5-heptenoate | 1422437-92-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-[methyl(15-phenylpentadecyl)amino]-2-oxoethyl (5Z)-7-{(1R,2R,3R,5R)-5-chloro-2-[(1E,4S)-4-(1-ethylcyclobutyl)-4-hydroxy-1-buten-1-yl]-3-hydroxycyclopentyl}-5-heptenoate
• 英文别名: [2-[methyl(15-phenylpentadecyl)amino]-2-oxoethyl] (Z)-7-[(1R,2R,3R,5R)-5-chloro-2-[(E,4S)-4-(1-ethylcyclobutyl)-4-hydroxybut-1-enyl]-3-hydroxycyclopentyl]hept-5-enoate
• CAS: 1422437-92-0
• 化学式: C₄₆H₇₄ClNO₅
• 分子量: 756.55
• InChiKey: CFEBGGKQEOCQON-PKIUJQMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.7
• 重原子数：
  53
• 可旋转键数：
  30
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  87.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• COMPOUND FOR TREATING CARTILAGE DISORDERS
  申请人：Obitsi Tetsuo

  公开号：US20140171388A1

  公开（公告）日：2014-06-19

  The present invention provides a compound of which active |form| is represented by a formula (A). and which can be injected into a joint cavity which is an affected part of disorders and can be accumulated in the joint cavity to exert the pharmacological effect thereof in a sustained manner, for the purpose of ameliorating cartilage disorders without developing any side effect. A compound according to the present invention, which is represented by a formula (I): (wherein all of symbols are as defined in the description), is a compound that can achieve the above-mentioned purpose. This compound does not exhibit any side effect on the cardiovascular system even when the compound is administered in an effective amount for exhibiting a cartilage regeneration activity, and is therefore extremely useful as a safe and effective preventive and/or therapeutic agent for cartilage disorders. Since a suspension produced using this compound can be injected without requiring the incision of the affected part, it can reduce the burden on patients, and is extremely useful as a medicinal agent.

  本发明提供一种化合物，其活性形式由公式（A）表示，并且可以注入到关节腔中，该关节腔是疾病的受影响部位，并且可以在关节腔中积累以持续发挥其药理作用，以改善软骨疾病而不产生任何副作用。本发明的化合物由公式（I）表示：（其中所有符号均如描述中所定义），是一种可以实现上述目的的化合物。即使在有效剂量下，该化合物对心血管系统也不会产生任何副作用，因此极其有用作为软骨疾病的安全有效的预防和/或治疗剂。由于使用该化合物制成的悬浮液可以注射而无需切开受影响的部位，因此可以减轻患者的负担，是一种非常有用的药物。
• US9085523B2
  申请人：——

  公开号：US9085523B2

  公开（公告）日：2015-07-21