[(1R,2S)-2,3-Dihydroxy-1-(2-oxo-2-pyridin-2-yl-ethyl)-propyl]-carbamic acid tert-butyl ester | 764715-59-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(1R,2S)-2,3-Dihydroxy-1-(2-oxo-2-pyridin-2-yl-ethyl)-propyl]-carbamic acid tert-butyl ester
• CAS: 764715-59-5
• 化学式: C₁₅H₂₂N₂O₅
• 分子量: 310.35
• InChiKey: WMDSNFVXYVTEPA-DGCLKSJQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  22.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  108.75
• 氢给体数：
  3.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  [(1R,2S)-2,3-Dihydroxy-1-(2-oxo-2-pyridin-2-yl-ethyl)-propyl]-carbamic acid tert-butyl ester 在 盐酸 、 sodium chlorite 、 sodium periodate 、 sodium dihydrogenphosphate 、 双氧水 作用下， 以 四氢呋喃 、 甲醇 、 乙腈 为溶剂， 反应 5.0h， 生成 (R)-2-Amino-4-oxo-4-pyridin-2-yl-butyric acid; hydrochloride
  参考文献：
  名称：

  Stereoselective synthesis and preliminary evaluation of new d-3-heteroarylcarbonylalanines as ligands of the NMDA receptor

  摘要：

  New N-heteroarylcarbonylalanines of the D-series were stereoselectively prepared from enoates derived from D-mannitol. These compounds were active in binding and functional assays of the NMDA sub-type of glutamate receptors. A pyridine derivative inhibited MK801 binding, protected neurons from excitotoxic damage and blocked NMDA-induced currents in neurons. A thiophene derivative positively modulated the NMDA receptor, possibly through the allosteric glycine site. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.062
• 作为产物：
  描述：

  [(R)-1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-oxo-3-pyridin-2-yl-propyl]-carbamic acid tert-butyl ester 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 16.0h， 以92%的产率得到[(1R,2S)-2,3-Dihydroxy-1-(2-oxo-2-pyridin-2-yl-ethyl)-propyl]-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Stereoselective synthesis and preliminary evaluation of new d-3-heteroarylcarbonylalanines as ligands of the NMDA receptor

  摘要：

  New N-heteroarylcarbonylalanines of the D-series were stereoselectively prepared from enoates derived from D-mannitol. These compounds were active in binding and functional assays of the NMDA sub-type of glutamate receptors. A pyridine derivative inhibited MK801 binding, protected neurons from excitotoxic damage and blocked NMDA-induced currents in neurons. A thiophene derivative positively modulated the NMDA receptor, possibly through the allosteric glycine site. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.062