3-Hydroxy-1-(4-methoxyphenyl)cyclobutanecarboxylic Acid | 1353636-86-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-Hydroxy-1-(4-methoxyphenyl)cyclobutanecarboxylic Acid
• 英文别名: 3-hydroxy-1-(4-methoxyphenyl)cyclobutane-1-carboxylic acid
• CAS: 1353636-86-8
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: LFTFNYUHJMESTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-Hydroxy-1-(4-methoxyphenyl)cyclobutanecarboxylic Acid 在 咪唑 、 sodium periodate 、 ruthenium(IV) oxide hydrate 、 lithium hydroxide monohydrate 、 硫酸 、 potassium tert-butylate 、 特戊酸银 、 三乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 乙酸乙酯 、 甲苯 为溶剂， 反应 102.0h， 生成
  参考文献：
  名称：

  Applications of C–H Functionalization Logic to Cyclobutane Synthesis

  摘要：

  The application of C-H functionalization logic to target-oriented synthesis provides an exciting new venue for the development of new and useful strategies in organic chemistry. In this article, C-H functionalization reactions are explored as an alternative approach to access pseudodimeric cyclobutane natural products, such as the dictazole and the piperarborenine families. The use of these strategies in a variety of complex settings highlights the subtle geometric, steric, and electronic effects at play in the auxiliary guided C-H fimctionalization of cyclobutanes.

  DOI：

  10.1021/jo4027148
• 作为产物：
  描述：

  对甲氧基苯乙酸 、 环氧氯丙烷 在 异丙基氯化镁 作用下， 以 四氢呋喃 为溶剂， 反应 15.25h， 生成 3-Hydroxy-1-(4-methoxyphenyl)cyclobutanecarboxylic Acid
  参考文献：
  名称：

  Applications of C–H Functionalization Logic to Cyclobutane Synthesis

  摘要：

  The application of C-H functionalization logic to target-oriented synthesis provides an exciting new venue for the development of new and useful strategies in organic chemistry. In this article, C-H functionalization reactions are explored as an alternative approach to access pseudodimeric cyclobutane natural products, such as the dictazole and the piperarborenine families. The use of these strategies in a variety of complex settings highlights the subtle geometric, steric, and electronic effects at play in the auxiliary guided C-H fimctionalization of cyclobutanes.

  DOI：

  10.1021/jo4027148