10,11-dihydro-10,10-dimethyl-7-(2-nitrophenyl)-7H-chromeno[4,3-b]quinoline-6,8(9H,12H)-dione | 1393713-67-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 10,11-dihydro-10,10-dimethyl-7-(2-nitrophenyl)-7H-chromeno[4,3-b]quinoline-6,8(9H,12H)-dione
• 英文别名: 10,10-dimethyl-7-(2-nitrophenyl)-7,10,11,12-tetrahydro-9H-chromeno[4,3-b]quinoline-6,8-dione；10,10-dimethyl-7-(2-nitrophenyl)-7,9,11,12-tetrahydrochromeno[4,3-b]quinoline-6,8-dione
• CAS: 1393713-67-1
• 化学式: C₂₄H₂₀N₂O₅
• 分子量: 416.433
• InChiKey: UBCNMVUKLHLICB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  31
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-羟基香豆素 在 ammonium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 5.7h， 生成 10,11-dihydro-10,10-dimethyl-7-(2-nitrophenyl)-7H-chromeno[4,3-b]quinoline-6,8(9H,12H)-dione
  参考文献：
  名称：

  An Efficient One-Pot Three-Component Synthesis of Highly Functionalized Coumarin Fused Indenodihydropyridine and Chromeno[4,3-b]quinoline Derivatives

  摘要：

  An efficient one-pot, three-component synthesis method of highly functionalized coumarin fused 7,13-dihydro-5-oxa-13-aza-indeno[2,1-b]phenanthrene and chromeno[4,3-b]quinoline derivatives was accomplished using aromatic aldehyde, 4-aminocoumarin and cyclic 1,3-dione in acetic acid at reflux temperature. Environmental-friendly protocol has advantages of high yields, creating three new bonds and one stereocenter in single operation. Further, XRD and DFT study confirmed the molecular structure, stability and different interaction in the crystal packing.

  DOI：

  10.3987/com-12-12494

文献信息

• An efficient four-component reaction for the synthesis of chromeno[4,3-b]quinolone derivatives
  作者：Azadeh Yahya-Meymandi、Hamideh Nikookar、Setareh Moghimi、Mohammad Mahdavi、Loghman Firoozpour、Ali Asadipour、Parviz Rashidi Ranjbar、Alireza Foroumadi

  DOI：10.1007/s13738-016-1027-3

  日期：2017.4

  Chromenoquinolines have been prepared via an efficient one-pot, multi-component reaction of 4-hydroxy coumarin, aqueous ammonia, dimedone and different aldehydes.

  铬喹啉是通过4-羟基香豆素，氨水，二甲酮和不同醛的高效一锅多组分反应制得的。