5-(5-hydroxy-4-(1-methyl-1H-indol-5-yl)-4H-1,2,4-triazol-3-yl)-3-isopropyl-1H-indazol-6-ol | 1464138-77-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-(5-hydroxy-4-(1-methyl-1H-indol-5-yl)-4H-1,2,4-triazol-3-yl)-3-isopropyl-1H-indazol-6-ol
• 英文别名: 3-(6-hydroxy-3-propan-2-yl-2H-indazol-5-yl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one
• CAS: 1464138-77-9
• 化学式: C₂₁H₂₀N₆O₂
• 分子量: 388.429
• InChiKey: CFZZPBFUEFBQKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  98.5
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] TRIAZOLE DERIVATIVES AS HSP90 INHIBITORS<br/>[FR] DÉRIVÉS DE TRIAZOLE COMME INHIBITEURS DE HSP90
  申请人：SYNTA PHARMACEUTICALS CORP

  公开号：WO2013148857A1

  公开（公告）日：2013-10-03

  A compound of structural formula (I) or (II): as HSP90 inhibitors that possess significantly improved bioavailability over comparative compounds, which are suitable for the treatment of hyperproliferative diseases such as cancer, infections, immune disorders, inflammation, and CNS related disorders.

  结构式（I）或（II）的化合物：作为HSP90抑制剂，具有明显改善的生物利用度，适用于治疗癌症、感染、免疫紊乱、炎症和中枢神经系统相关疾病等高增殖性疾病。
• TRIAZOLE DERIVATIVES AS HSP90 INHIBITORS
  申请人：Synta Pharmaceuticals Corp.

  公开号：US20150051203A1

  公开（公告）日：2015-02-19

  A compound of structural formula (I) or (II): as HSP90 inhibitors that possess significantly improved bioavailability over comparative compounds, which are suitable for the treatment of hyperproliferative diseases such as cancer, infections, immune disorders, inflammation, and CNS related disorders.

  化学结构式(I)或(II)的化合物，作为HSP90抑制剂具有明显改善的生物利用度，适用于治疗增殖过度性疾病，如癌症、感染、免疫障碍、炎症和中枢神经系统相关疾病。