N3-benzoyl-2'-O-methoxycarbonylmethyl-1',3'-O-(1,1,3,3-tetraisopropyldisiloxane)uridine | 1207847-50-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N3-benzoyl-2'-O-methoxycarbonylmethyl-1',3'-O-(1,1,3,3-tetraisopropyldisiloxane)uridine
• CAS: 1207847-50-4
• 化学式: C₃₁H₄₆N₂O₁₀Si₂
• 分子量: 662.885
• InChiKey: SNODMVYEXMAALP-AZUODYCOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.11
• 重原子数：
  45.0
• 可旋转键数：
  9.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  133.52
• 氢给体数：
  0.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  N3-benzoyl-2'-O-methoxycarbonylmethyl-1',3'-O-(1,1,3,3-tetraisopropyldisiloxane)uridine 在 triethylamine tris(hydrogen fluoride) 作用下， 以 四氢呋喃 为溶剂， 以62%的产率得到N3-benzoyl-2'-O-methoxycarbonylmethyluridine
  参考文献：
  名称：

  Synthesis and Properties of Oligodeoxyribonucleotides Bearing a Polyamino Group at the 2′ Position via 2′-O-Carbamoylmethyl and 2′-S-Carbamoylmethyl groups

  摘要：

  An oligodeoxyribonucleotide containing 2'-O-methoxycarbonylmethyluridine was synthesized and converted into several 2'-modified oligodeoxyribonucleotides by a postsynthetic modification method. Using this method, oligodeoxyribonucleotides bearing a polyamine at the 2' Position were easily prepared, which could form duplexes with either complementary DNA or RNA.

  DOI：

  10.1080/15257770903307185
• 作为产物：
  描述：

  N³-benzoyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 、 溴乙酸甲酯 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.5h， 以88%的产率得到N3-benzoyl-2'-O-methoxycarbonylmethyl-1',3'-O-(1,1,3,3-tetraisopropyldisiloxane)uridine
  参考文献：
  名称：

  Synthesis and Properties of Oligodeoxyribonucleotides Bearing a Polyamino Group at the 2′ Position via 2′-O-Carbamoylmethyl and 2′-S-Carbamoylmethyl groups

  摘要：

  An oligodeoxyribonucleotide containing 2'-O-methoxycarbonylmethyluridine was synthesized and converted into several 2'-modified oligodeoxyribonucleotides by a postsynthetic modification method. Using this method, oligodeoxyribonucleotides bearing a polyamine at the 2' Position were easily prepared, which could form duplexes with either complementary DNA or RNA.

  DOI：

  10.1080/15257770903307185