3,3 difluoro-5β,20α,22α,25R-spirostane | 349082-97-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3,3 difluoro-5β,20α,22α,25R-spirostane
• 英文别名: (1R,2S,4S,5'R,6R,7S,8R,9S,12S,13S,18R)-16,16-difluoro-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]
• CAS: 349082-97-9
• 化学式: C₂₇H₄₂F₂O₂
• 分子量: 436.626
• InChiKey: OBILTJVVXAWJFK-WOUVDBECSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  31
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Substituted sapogenins and their use
  申请人：PHYTOPHARM PLC.

  公开号：US20030158161A1

  公开（公告）日：2003-08-21

  The invention discloses substituted sapogenins and their use in the treatment of cognitive disfunction and similar conditions. Methods of treatment and pharmaceutical composition are also disclosed

  该发明揭示了替代皂甙苷及其在治疗认知功能障碍和类似疾病中的用途。同时还揭示了治疗方法和药物组合。
• Therapeutic methods and uses of sapogenins and their derivatives
  申请人：Rees Daryl

  公开号：US20050130948A1

  公开（公告）日：2005-06-16

  The invention discloses therapeutic methods and uses of certain steroidal sapogenins, related compounds and derivatives thereof, in the treatment of non-cognitive neurodegeneration, non-cognitive neuromuscular degeneration, motor-sensory neurodegeneration or receptor dysfunction or loss in the absence of cognitive, neural and neuromuscular impairment.

  本发明公开了某些甾体苷元、相关化合物及其衍生物在治疗非认知性神经变性、非认知性神经肌肉变性、运动感觉神经变性或在无认知、神经和神经肌肉损伤情况下的受体功能障碍或丧失方面的治疗方法和用途。
• SUBSTITUTED SAPOGENINS AND THEIR USE
  申请人：PHYTOPHARM PLC

  公开号：EP1246835B1

  公开（公告）日：2009-01-07
• [EN] SUBSTITUTED SAPOGENINS AND THEIR USE<br/>[FR] SAPOGENINES SUBSTITUEES ET LEUR UTILISATION
  申请人：PHYTOPHARM PLC

  公开号：WO2001049703A2

  公开（公告）日：2001-07-12

  The invention discloses substituted sapogenins and their use in the treatment of cognitive disfunction and similar conditions. Methods of treatment and pharmaceutical composition are also disclosed.