p-Menthan-carbonsaeure-(3)-methylester | 92037-62-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: p-Menthan-carbonsaeure-(3)-methylester
• 英文别名: Methyl 5-methyl-2-propan-2-ylcyclohexane-1-carboxylate
• CAS: 92037-62-2
• 化学式: C₁₂H₂₂O₂
• 分子量: 198.305
• InChiKey: WSNSSGPONUMHFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Peptides capable of inhibiting the activity of HIV protease, their preparation and their therapeutic use
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0587311A1

  公开（公告）日：1994-03-16

  Compounds of formula (I) : [wherein: R¹ is hydrogen, alkyl, aralkyl, -CORa, -CORb, -CSRa, -CSRb, -SO₂Rb, -CONHRb, -CSNHRb, -CONRbRb or -CSNRbRb; R² is hydrogen or alkyl; R³ is hydrogen, alkylidene, substituted alkyl, or Rb; R⁴ is optionally substituted alkyl, cycloalkyl, or aryl; R⁵ is RbO-, RbRbN-, RbHN-, aralkyloxycarbonyloxy or aralkyloxycarbonylamino, or R⁵ is -(CH₂)p-D-(CH₂)r- [where D is a single bond, carbonyl, oxygen, sulphur, -NH-, -(CH₂=CH₂)- or -NHCO-; and p and r are each 0 or an integer from 1 to 5]; A is -(CH₂)m-B-(CH₂)n- [where B is a single bond, carbonyl, oxygen, sulphur, -NH-, -(CH₂=CH₂)- or -NHCO-; and m and n are each 0 or an integer from 1 to 5]; Ra is alkoxy, aralkyloxy, aryloxy or alkoxycarbonyl; Rb is optionally substituted alkyl, cycloalkyl, heterocyclic, aryl or arylalkenyl]; and pharmaceutically acceptable salts and esters thereof and pro-drugs therefor, have the ability to inhibit the activity of HIV protease and may thus be used for the treatment and prophylaxis of AIDS.

  化合物的化学式为(I)：[其中：R¹为氢，烷基，芳基烷基，-CORa，-CORb，-CSRa，-CSRb，-SO₂Rb，-CONHRb，-CSNHRb，-CONRbRb或-CSNRbRb；R²为氢或烷基；R³为氢，烷基亚甲基，取代烷基或Rb；R⁴为可选取代的烷基，环烷基或芳基；R⁵为RbO-，RbRbN-，RbHN-，芳基烷氧羰氧基氧或芳基烷氧羰氨基，或R⁵为-(CH₂)p-D-(CH₂)r- [其中D为单键，酰基，氧，硫，-NH-，-(CH₂=CH₂)-或-NHCO-；p和r分别为0或1到5的整数]；A为-(CH₂)m-B-(CH₂)n- [其中B为单键，酰基，氧，硫，-NH-，-(CH₂=CH₂)-或-NHCO-；m和n分别为0或1到5的整数]；Ra为烷氧基，芳基烷氧基，芳氧基或烷氧羰基；Rb为可选取代的烷基，环烷基，杂环，芳基或芳基烷烯基]；以及其药学上可接受的盐和酯以及其前药，具有抑制HIV蛋白酶活性的能力，因此可用于治疗和预防艾滋病。
• Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use
  申请人：Sankyo Company Limited

  公开号：EP0536936A1

  公开（公告）日：1993-04-14

  Compounds of formula (I): [in which: R¹, R² and R³ are the same or different and each represents a hydrogen atom, an optionally substituted alkanoyl group or an alkenylcarbonyl group, provided that at least one of R¹, R² and R³ represents an unsubstituted alkanoyl group having from 5 to 24 carbon atoms, said substituted alkanoyl group or said alkenylcarbonyl group; and one of R⁴ and R⁵ represents a hydrogen atom and the other represents a cyano group]; have valuable anti-tumour activity.

  式子（I）的化合物：[其中：R¹、R²和R³相同或不同，每个代表氢原子、可选取代的脂肪酰基团或烯基羰基团，前提是至少有一个R¹、R²和R³代表有5到24个碳原子的未取代脂肪酰基团，或者是所述取代的脂肪酰基团或所述烯基羰基团；R⁴和R⁵中的一个代表氢原子，另一个代表氰基]，具有有价值的抗肿瘤活性。
• TRICYCLIC CYTOPROTECTIVE COMPOUNDS
  申请人：Wulfert Ernst

  公开号：US20090259043A1

  公开（公告）日：2009-10-15

  Compounds of formula (I): [in which: X is a group of formula >CR 1 R 2 or >SO 2 ; Y is a group of formula >NH or >CR 1 R 2 ; Z is a group of formula >C═O or >CH 2 or a direct bond; R 1 is hydrogen and R 2 is hydrogen, carboxy or hydroxy; or R 1 and R 2 together represent an oxo group, a methylenedioxy group or a hydroxyimino group; R 3 is hydrogen or lower alkyl; R 4 represents two hydrogen atoms, or an oxo or hydroxyimino group; R 5 is hydrogen, lower alkyl or halogen; R 6 is hydrogen, lower alkoxy or carboxy; R 7 and R 8 are each hydrogen, lower alkyl or halogen; and pharmaceutically acceptable salts and esters thereof can be used for the treatment or prophylaxis of acute or chronic neurodegenerative diseases or conditions such as Alzheimer's Disease, Parkinson's Disease, Huntington's Chorea, Multiple Sclerosis or the sequelae to acute ischaemic events such as heart attack, stroke or head injury and for protection against ischaemic damage to tissues of peripheral organs.

  式(I)的化合物：[其中：X是公式>CR1R2或>SO2的基团；Y是公式>NH或>CR1R2的基团；Z是公式>C═O或>CH2或直接键的基团；R1是氢原子，R2是氢原子，羧基或羟基；或R1和R2一起代表氧代基、甲亚基二氧基基团或羟基亚胺基团；R3是氢原子或较低的烷基；R4代表两个氢原子或氧代基或羟基亚胺基团；R5是氢原子、较低的烷基或卤素；R6是氢原子、较低的烷氧基或羧基；R7和R8均为氢原子、较低的烷基或卤素；以及其药学上可接受的盐和酯，可用于治疗或预防急性或慢性神经退行性疾病或病症，如阿尔茨海默病、帕金森病、亨廷顿舞蹈病、多发性硬化症或急性缺血事件的后遗症，如心脏病发作、中风或头部损伤，并用于保护外周器官组织免受缺血性损伤。
• Tricyclic Cytoprotective Compounds
  申请人：Wulfert Ernst

  公开号：US20080146644A1

  公开（公告）日：2008-06-19

  Compounds of formula (I): [in which: X is a group of formula >CR 1 R 2 or >SO 2 ; Y is a group of formula >NH or >CR 1 R 2 ; Z is a group of formula >C═O or >CH 2 or a direct bond; R 1 is hydrogen and R 2 is hydrogen, carboxy or hydroxy; or R 1 and R 2 together represent an oxo group, a methylenedioxy group or a hydroxyimino group; R 3 is hydrogen or lower alkyl; R 4 represents two hydrogen atoms, or an oxo or hydroxyimino group; R 5 is hydrogen, lower alkyl or halogen; R 6 is hydrogen, lower alkoxy or carboxy; R 7 and R 8 are each hydrogen, lower alkyl or halogen; and pharmaceutically acceptable salts and esters thereof can be used for the treatment or prophylaxis of acute or chronic neurodegenerative diseases or conditions such as Alzheimer's Disease, Parkinson's Disease, Huntington's Chorea, Multiple Sclerosis or the sequelae to acute ischaemic events such as heart attack, stroke or head injury and for protection against ischaemic damage to tissues of peripheral organs.

  化合物的公式 (I)：[其中：X 是公式 >CR1R2 或 >SO2 的基团；Y 是公式 >NH 或 >CR1R2 的基团；Z 是公式 >C═O 或 >CH2 或直接键；R1 是氢原子，R2 是氢原子，羧基或羟基；或者 R1 和 R2 一起表示一个氧代基团、一个甲二氧基基团或一个羟肟基团；R3 是氢原子或低碳基；R4 表示两个氢原子，或一个氧代基团或羟肟基团；R5 是氢原子、低碳基或卤素；R6 是氢原子、低烷氧基或羧基；R7 和 R8 分别是氢原子、低碳基或卤素；以及其药学上可接受的盐和酯，可用于治疗或预防急性或慢性神经退行性疾病或病症，如阿尔茨海默病、帕金森病、亨廷顿舞蹈病、多发性硬化症或急性缺血事件的后遗症，如心脏病发作、中风或头部损伤，并保护外围器官组织免受缺血损伤。
• Kationische Farbstoffe, ihre Herstellung und Verwendung zum Färben kationisch färbbarer Fasern und Papier
  申请人：BAYER AG

  公开号：EP0050263A1

  公开（公告）日：1982-04-28

  Kationische Farbstoffe der allgemeinen Formel worin R für Wasserstoff oder einen gegebenenfalls durch nichtionische Reste substituierten Alkylrest mit maximal 8 C-Atomen, R1 für Wasserstoff oder einen gegebenenfalls durch nichtionische Reste substituierten Alkylrest mit maximal 4 C-Atomen und An- für ein Anion stehen, und worin die Benzol- und Naphthalinringe in der Farbstoffchemie übliche, nichtionische Reste enthalten können, werden zum Färben von natürlichen und synthetischen kationisch färbbaren Fasern und von Papier verwendet.

  通式中 R 代表氢或最多有 8 个碳原子的烷基（可被非离子基取代），R1 代表氢或最多有 4 个碳原子的烷基（可被非离子基取代），An- 代表阴离子的阳离子染料，其中苯环和萘环可能含有染料化学中常用的非离子基，可用于天然和合成阳离子可染纤维和纸张的染色。