2,2-difluoro-2-(2-nitrophenylsulfonyl)-1-phenylethanone | 1257881-30-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-difluoro-2-(2-nitrophenylsulfonyl)-1-phenylethanone
• CAS: 1257881-30-3
• 化学式: C₁₄H₉F₂NO₅S
• 分子量: 341.292
• InChiKey: RUANZUGVTXVBCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.84
• 重原子数：
  23.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  94.35
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  邻硝基苯硫酚 在 sodium carbonate 、 Selectfluor 、 间氯过氧苯甲酸 作用下， 以 甲醇 为溶剂， 反应 0.33h， 生成 2,2-difluoro-2-(2-nitrophenylsulfonyl)-1-phenylethanone
  参考文献：
  名称：

  An efficient fluorination of β-ketosulfones promoted by a room-temperature ionic liquid at ambient conditions under ultrasound irradiation using Selectfluor™ F-TEDA-BF4

  摘要：

  The fluorination reaction involving a beta-ketosulfones by Selectfluor (TM) was efficiently promoted by the ionic liquid, [Hbim]BF4 (IL) as a reaction medium with methanol as co-solvent at room temperature under ultrasonic irradiation to afford the corresponding mono and difluoro-beta-ketosulfones in excellent yields. The advantages of this method include among others the use of a recyclable, non-volatile ionic liquid, which promotes this protocol under room temperature without the requirement of any added catalyst under ultrasonic irradiation. (C) 2010 Mohammad Reza Poor Heravi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2010.06.030