| 227596-96-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 227596-96-5
• 化学式: C₄₅H₇₅NO₃₅S
• 分子量: 1222.14
• InChiKey: HGLPBROFAUYKCF-MKWHQSKQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -14.79
• 重原子数：
  82.0
• 可旋转键数：
  10.0
• 环数：
  21.0
• sp3杂化的碳原子比例：
  0.98
• 拓扑面积：
  562.92
• 氢给体数：
  22.0
• 氢受体数：
  36.0

反应信息

• 作为产物：
  描述：

  6-monodeoxy-6-monoamino-β-cyclodextrin hydrochloride 、 3-巯基丙酸 在 1-羟基苯并三唑 、 N,N-二异丙基乙胺 、 N,N'-二异丙基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以86%的产率得到
  参考文献：
  名称：

  Superselective Targeting Using Multivalent Polymers

  摘要：

  Despite their importance for material and life sciences, multivalent interactions between polymers and surfaces remain poorly understood. Combining recent achievements of synthetic chemistry and surface characterization, we have developed a well-defined and highly specific model system based on host/guest interactions. We use this model to study the binding of hyaluronic acid functionalized with host molecules to tunable surfaces displaying different densities of guest molecules. Remarkably, we find that the surface density of bound polymer increases faster than linearly with the surface density of binding sites. Based on predictions from a simple analytical model, we propose that this superselective behavior arises from a combination of enthalpic and entropic effects upon binding of nanoobjects to surfaces, accentuated by the ability of polymer chains to interpenetrate.

  DOI：

  10.1021/ja411138s