(3aR,5S,6S,7R,7aR)-5-(chloromethyl)-2-(ethylamino)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol | 1424256-36-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3aR,5S,6S,7R,7aR)-5-(chloromethyl)-2-(ethylamino)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
• 英文别名: (3aR,5S,6S,7R,7aR)-5-(chloromethyl)-2-(ethylamino)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazol-6,7-diol；(3aR,5S,6S,7R,7aR)-5-(chloromethyl)-2-(ethylamino)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-diol；(3aR,5S,6S,7R,7aR)-5-(chloromethyl)-2-ethylimino-1,3a,5,6,7,7a-hexahydropyrano[3,2-d][1,3]thiazole-6,7-diol
• CAS: 1424256-36-9
• 化学式: C₉H₁₅ClN₂O₃S
• 分子量: 266.749
• InChiKey: DUHDRVZYGNHJJZ-FMDGEEDCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  99.4
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  thiamet-G 在 N-氯代丁二酰亚胺 、 三苯基膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以12%的产率得到(3aR,5S,6S,7R,7aR)-5-(chloromethyl)-2-(ethylamino)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
  参考文献：
  名称：

  [EN] PYRANO [3, 2 - D] [1, 3] THIAZOLE AS GLYCOSIDASE INHIBITORS
  [FR] PYRANO[3,2-D][1,3]THIAZOLE FORMANT DES INHIBITEURS DE LA GLYCOSIDASE

  摘要：

  化合物的新颖结构如下（I），其中R1至R4和X的含义根据要求，是葡萄糖苷酶抑制剂，可用于治疗阿尔茨海默病。

  公开号：

  WO2013028715A1

文献信息

• Pyrano [3,2-D][1,3]thiazole as glycosidase inhibitors
  申请人：Donnely Marianne

  公开号：US08884023B2

  公开（公告）日：2014-11-11

  Novel compounds of formula (I) wherein R1 to R4 and X have the meaning according to the claims, are glucosidase inhibitors, and can be employed, inter alia, for the treatment of Alzheimer's disease.

  式（I）的新化合物，其中R1至R4和X的含义如权利要求所述，是葡萄糖苷酶抑制剂，可用于治疗阿尔茨海默病等疾病。
• Pyrano[3,2-D][1,3]thiazole as glycosidase inhibitors
  申请人：Donnelly Marianne

  公开号：US20140243370A1

  公开（公告）日：2014-08-28

  Novel compounds of formula (I) wherein R 1 to R 4 and X have the meaning according to the claims, are glucosidase inhibitors, and can be employed, inter alia, for the treatment of Alzheimer's disease.

  公式（I）的新化合物，其中R1至R4和X的含义根据权利要求书中所述，是葡萄糖苷酶抑制剂，可用于治疗阿尔茨海默病等疾病。
• PYRANO [3, 2 - D][1, 3]THIAZOLE AS GLYCOSIDASE INHIBITORS
  申请人：Merck Patent GmbH

  公开号：EP2748171A1

  公开（公告）日：2014-07-02
• GLYCOSIDASE INHIBITORS AND USES THEREOF
  申请人：MEADWESTVACO PACKAGING SYSTEMS, LLC

  公开号：US20160194337A1

  公开（公告）日：2016-07-07

  A locking arrangement secures together first and second panels. The arrangement includes locking tabs ( 54, 56, 58 ) projecting from an end edge ( 64 ) of the first panel ( 12 ) and locking slits ( 50 a, 50 b, 50 c ) in the second panel ( 28 ). Each locking slit is provided for receiving a respective one of the locking tabs. The locking tabs and the locking slits are engageable by relative sliding movement with each other. At least one of the locking tabs and locking slits is configured to secure the first and second panels in a first overlapping position while at least another one of the locking tabs and locking slits is configured to secure the first and second panels in a second overlapping position.
• US8884023B2
  申请人：——

  公开号：US8884023B2

  公开（公告）日：2014-11-11