2-(trimethylsilyl)ethyl(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-acetyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-acetyl-β-D-glucopyranosyl)-(1-4)-(6-deoxy-2,3-di-O-methyl-6-phthalimido-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-methyl-β-D-glucopyranosyl)-(1-4)-[(2,3,6-tri-O-methyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-methyl-β-D-glucopyranosyl)-(1-4)]3-2,3-di-O-methyl-β-D-glucopyranoside | 405159-38-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(trimethylsilyl)ethyl(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-acetyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-acetyl-β-D-glucopyranosyl)-(1-4)-(6-deoxy-2,3-di-O-methyl-6-phthalimido-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-methyl-β-D-glucopyranosyl)-(1-4)-[(2,3,6-tri-O-methyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-methyl-β-D-glucopyranosyl)-(1-4)]3-2,3-di-O-methyl-β-D-glucopyranoside
• CAS: 405159-38-8
• 化学式: C₁₃₀H₂₀₇NO₇₂Si
• 分子量: 2964.12
• InChiKey: QGOVGSGKXIDCTA-WNJZBWMNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.43
• 重原子数：
  204.0
• 可旋转键数：
  74.0
• 环数：
  14.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  772.88
• 氢给体数：
  1.0
• 氢受体数：
  72.0

反应信息

• 作为反应物：
  描述：

  2-(trimethylsilyl)ethyl(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-acetyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-acetyl-β-D-glucopyranosyl)-(1-4)-(6-deoxy-2,3-di-O-methyl-6-phthalimido-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-methyl-β-D-glucopyranosyl)-(1-4)-[(2,3,6-tri-O-methyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-methyl-β-D-glucopyranosyl)-(1-4)]3-2,3-di-O-methyl-β-D-glucopyranoside 、 乙酸酐 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 2-(trimethylsilyl)ethyl(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-acetyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-acetyl-β-D-glucopyranosyl)-(1-4)-(6-deoxy-2,3-di-O-methyl-6-phthalimido-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-methyl-β-D-glucopyranosyl)-(1-4)-[(2,3,6-tri-O-methyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-methyl-β-D-glucopyranosyl)-(1-4)]3-6-O-acetyl-2,3-di-O-methyl-β-D-glucopyranoside
  参考文献：
  名称：

  Novel polysaccharides with antithrombotic activity comprising at least one covalent bond with biotin or a biotin derivative

  摘要：

  本发明涉及具有抗血栓活性的新型合成多糖，其至少与生物素或生物素衍生物之一形成共价键，以及利用亲和素或链球菌素的过程，使得可以中和这些多糖。

  公开号：

  US20060160768A1
• 作为产物：
  描述：

  2-(trimethylsilyl)ethyl(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-acetyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-acetyl-β-D-glucopyranosyl)-(1-4)-(6-deoxy-2,3-di-O-methyl-6-phthalimido-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-methyl-β-D-glucopyranosyl)-(1-4)-[(2,3,6-tri-O-methyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-methyl-β-D-glucopyranosyl)-(1-4)]3-6-O-benzyl-2,3-di-O-methyl-β-D-glucopyranoside 在 palladium 10% on activated carbon 氢气 作用下， 以 溶剂黄146 为溶剂， 反应 2.5h， 生成 2-(trimethylsilyl)ethyl(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-acetyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-acetyl-β-D-glucopyranosyl)-(1-4)-(6-deoxy-2,3-di-O-methyl-6-phthalimido-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-methyl-β-D-glucopyranosyl)-(1-4)-[(2,3,6-tri-O-methyl-α-D-glucopyranosyl)-(1-4)-(2,3,6-tri-O-methyl-β-D-glucopyranosyl)-(1-4)]3-2,3-di-O-methyl-β-D-glucopyranoside
  参考文献：
  名称：

  Novel polysaccharides with antithrombotic activity comprising at least one covalent bond with biotin or a biotin derivative

  摘要：

  本发明涉及具有抗血栓活性的新型合成多糖，其至少与生物素或生物素衍生物之一形成共价键，以及利用亲和素或链球菌素的过程，使得可以中和这些多糖。

  公开号：

  US20060160768A1