2-methoxy-10-propylacridin-9(10H)-one | 66300-92-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-methoxy-10-propylacridin-9(10H)-one
• 英文别名: 2-Methoxy-10-n-propyl-9-acridanon；2-Methoxy-10-propylacridin-9-one
• CAS: 66300-92-3
• 化学式: C₁₇H₁₇NO₂
• 分子量: 267.327
• InChiKey: AVKZNDGEBDPRNS-UHFFFAOYSA-N

物化性质

• 熔点：
  90 °C
• 沸点：
  438.5±44.0 °C(Predicted)
• 密度：
  1.153±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methoxy-10-propylacridin-9(10H)-one 、 2-(2-cyanoacetamido)ethyl methacrylate 在 四氯化钛 、 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 8.25h， 生成 (E)-2-(2-cyano-2-(2-methoxy-10-propylacridin-9(10H)ylidene)acetamido)ethyl methacrylate
  参考文献：
  名称：

  [EN] PHOTOSTABLE MIMICS OF MACULAR PIGMENT
  [FR] ANALOGUES PHOTOSTABLES DE PIGMENT MACULAIRE

  摘要：

  Described are visible light absorbing compounds. The compounds have a visible light absorption maximum between 430 and 480 nm and a full width half maximum (FWHM) at the visible light absorption maximum of at least 35 nm and up to 150 nanometers, wherein the compounds are photostable. The compounds are also thermally stable. The compounds substantially mimic the visible light absorbance properties of macular pigment while remaining photostable and thermally stable. The compounds may be used in a variety of articles, including ophthalmic devices. Formula (I):

  公开号：

  WO2022130089A1
• 作为产物：
  描述：

  2-碘苯甲酸 在 Eaton's reagent 、 铜 、 potassium carbonate 、 caesium carbonate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 47.0h， 生成 2-methoxy-10-propylacridin-9(10H)-one
  参考文献：
  名称：

  [EN] PHOTOSTABLE MIMICS OF MACULAR PIGMENT
  [FR] ANALOGUES PHOTOSTABLES DE PIGMENT MACULAIRE

  摘要：

  Described are visible light absorbing compounds. The compounds have a visible light absorption maximum between 430 and 480 nm and a full width half maximum (FWHM) at the visible light absorption maximum of at least 35 nm and up to 150 nanometers, wherein the compounds are photostable. The compounds are also thermally stable. The compounds substantially mimic the visible light absorbance properties of macular pigment while remaining photostable and thermally stable. The compounds may be used in a variety of articles, including ophthalmic devices. Formula (I):

  公开号：

  WO2022130089A1

文献信息

• BLANCHARD C.; FABRE J.-M.; MONTGINOUL C.; CHAFFIA BRAT ALI; TORREILLES E.+, J. HETEROCYCL. CHEM., 1978, 15, NO 1, 149-153
  作者：BLANCHARD C.、 FABRE J.-M.、 MONTGINOUL C.、 CHAFFIA BRAT ALI、 TORREILLES E.+

  DOI：——

  日期：——
• PHOTOSTABLE MIMICS OF MACULAR PIGMENT
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US20220194944A1

  公开（公告）日：2022-06-23

  Described are visible light absorbing compounds. The compounds have a visible light absorption maximum between 430 and 480 nm and a full width half maximum (FWHM) at the visible light absorption maximum of at least 35 nm and up to 150 nanometers, wherein the compounds are photostable. The compounds are also thermally stable. The compounds substantially mimic the visible light absorbance properties of macular pigment while remaining photostable and thermally stable. The compounds may be used in a variety of articles, including ophthalmic devices.