dimethyl 5-(4,4-dimethyl-2-oxooxazolidin-3-yl)-6-(2-hydroxy-6-methylphenyl)-4,7-dimethyl-1,3-dihydro-2H-indene-2,2-dicarboxylate | 1174417-44-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: dimethyl 5-(4,4-dimethyl-2-oxooxazolidin-3-yl)-6-(2-hydroxy-6-methylphenyl)-4,7-dimethyl-1,3-dihydro-2H-indene-2,2-dicarboxylate
• CAS: 1174417-44-7
• 化学式: C₂₇H₃₁NO₇
• 分子量: 481.546
• InChiKey: MGACMCOWHNAMJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.15
• 重原子数：
  35.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  102.37
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  dimethyl 5-(4,4-dimethyl-2-oxooxazolidin-3-yl)-6-(2-hydroxy-6-methylphenyl)-4,7-dimethyl-1,3-dihydro-2H-indene-2,2-dicarboxylate 、 左旋樟脑-10-磺酰氯 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以56%的产率得到
  参考文献：
  名称：

  A rhodium(I)-xylyl-BINAP catalyzed asymmetric ynamide-[2+2+2] cycloaddition in the synthesis of optically enriched N,O-biaryls

  摘要：

  A rhodium(I)-xylyl-BINAP catalyzed asymmetric [2+2+2] cycloaddition of achiral conjugated aryl ynamides with various diynes is described here. This asymmetric cycloaddition provides a series of structurally interesting chiral N,O-biaryls with excellent enantioselectivity along with a modest diastereoselectivity, with respect to both C-C and C-N axial chirality. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.03.078
• 作为产物：
  描述：

  Dimethyl 5-(4,4-dimethyl-2-oxo-1,3-oxazolidin-3-yl)-6-(2-methoxy-6-methylphenyl)-4,7-dimethyl-1,3-dihydroindene-2,2-dicarboxylate 在 三溴化硼 、 水 作用下， 以 二氯甲烷 为溶剂， 以67%的产率得到dimethyl 5-(4,4-dimethyl-2-oxooxazolidin-3-yl)-6-(2-hydroxy-6-methylphenyl)-4,7-dimethyl-1,3-dihydro-2H-indene-2,2-dicarboxylate
  参考文献：
  名称：

  A rhodium(I)-xylyl-BINAP catalyzed asymmetric ynamide-[2+2+2] cycloaddition in the synthesis of optically enriched N,O-biaryls

  摘要：

  A rhodium(I)-xylyl-BINAP catalyzed asymmetric [2+2+2] cycloaddition of achiral conjugated aryl ynamides with various diynes is described here. This asymmetric cycloaddition provides a series of structurally interesting chiral N,O-biaryls with excellent enantioselectivity along with a modest diastereoselectivity, with respect to both C-C and C-N axial chirality. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.03.078