desacyl-theasaponin F | 877879-77-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: desacyl-theasaponin F
• CAS: 877879-77-1
• 化学式: C₅₃H₈₄O₂₆
• 分子量: 1137.23
• InChiKey: KJWDGIJYMFLQHY-CPPLEPQUSA-N

物化性质

• 密度：
  1.55±0.1 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  desacyl-theasaponin F 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以2.4 mg的产率得到desacyl-assamsaponin D
  参考文献：
  名称：

  Triterpene Saponins with Gastroprotective Effects from Tea Seed (the Seeds of Camellia sinensis)

  摘要：

  Six new triterpene saponins, theasaponins A(1) (1), A(2) (2), A(3) (3), F-2 (4), F-2 (5), and F-3 (6), were isolated from the saponin fraction of the seeds of Camellia sinensis. The stereostructures of 1-6 were elucidated on the basis of chemical and physicochemical evidence. Theasaponin A2 (2) showed an inhibitory effect on ethanol-induced gastric mucosal lesions in rats at a dose of 5.0 mg/kg, p.o., and its activity was more potent than that of omeplazole. Structure-activity relationships for theasaponins on ethanol-induced gastroprotective activities may be suggested as follows: (1) the 28-acetyl moiety enhances activity; (2) theasaponins having a 23-aldehyde group exhibit more potent activities than those with a 23-hydroxymethyl group or a 23-methoxycarbonyl group.

  DOI：

  10.1021/np058097w
• 作为产物：
  描述：

  theasaponin F3 在 氢氧化钾 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 以2.2 mg的产率得到desacyl-theasaponin F
  参考文献：
  名称：

  Triterpene Saponins with Gastroprotective Effects from Tea Seed (the Seeds of Camellia sinensis)

  摘要：

  Six new triterpene saponins, theasaponins A(1) (1), A(2) (2), A(3) (3), F-2 (4), F-2 (5), and F-3 (6), were isolated from the saponin fraction of the seeds of Camellia sinensis. The stereostructures of 1-6 were elucidated on the basis of chemical and physicochemical evidence. Theasaponin A2 (2) showed an inhibitory effect on ethanol-induced gastric mucosal lesions in rats at a dose of 5.0 mg/kg, p.o., and its activity was more potent than that of omeplazole. Structure-activity relationships for theasaponins on ethanol-induced gastroprotective activities may be suggested as follows: (1) the 28-acetyl moiety enhances activity; (2) theasaponins having a 23-aldehyde group exhibit more potent activities than those with a 23-hydroxymethyl group or a 23-methoxycarbonyl group.

  DOI：

  10.1021/np058097w