| 1430561-01-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• CAS: 1430561-01-5
• 化学式: C₄₇H₃₀N₄O₄Zn
• 分子量: 780.17
• InChiKey: AHKOHLFSCLZYFO-RUNSENEXSA-N

反应信息

• 作为反应物：
  描述：

  、 在 tetrakis(actonitrile)copper(I) hexafluorophosphate 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 0.42h， 以65%的产率得到
  参考文献：
  名称：

  Synthesis and biological evaluation of Foscan® bile acid conjugates to target esophageal cancer cells

  摘要：

  Porphyrins and chlorins such as Foscan (R) have a natural proclivity to accumulate in cancer cells. This trait has made them good candidates for photosensitizers and as imaging agents in phototherapy. In order to improve on cellular selectivity to lower post-treatment photosensitivity bile acid porphyrin bioconjugates have been prepared and investigated in esophageal cancer cells. Bile acids which are known to selectively bind to, or be readily taken up by cancer cells were chosen as targeting moieties. Synthesis of the conjugates was achieved via selective nucleophilic monofunctionalization of 5,10,15,20-tetrahydroxyphenylporphyrins with propargyl bromide followed by Cu(I) mediated cycloaddition with bile acid azides in good yields. The compounds were readily taken up by esophageal cancer cells but showed no PDT activity. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.03.040