4,4'-(十氧-4,7-甲醛)双酚 | 1943-97-1

• 物质功能分类: 化学试剂 - 有机试剂 - 芳香醇
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4,4'-(十氧-4,7-甲醛)双酚
• 中文别名: 4,4-(八氢-4,7-亚甲基-5H-茚-5-亚基)双酚；4,4-(八氢-4,7-甲烷基-5H-茚-5-亚基) 二苯酚
• 英文名称: 4,4'-(octahydro-4,7-methano-5H-inden-5-ylidene)bisphenol
• 英文别名: 5,5-bis(4-hydroxyphenyl)tricyclo[5.2.1.0^2,6]decane；8,8-bis(4'-hydroxyphenyl)-tricyclo[5.2.1.02,6 ] decane；Phenol, 4,4'-(octahydro-4,7-methano-5H-inden-5-ylidene)bis-；4-[8-(4-hydroxyphenyl)-8-tricyclo[5.2.1.02,6]decanyl]phenol
• CAS: 1943-97-1
• 化学式: C₂₂H₂₄O₂
• 分子量: 320.431
• InChiKey: WWCSTJWKTAXUGJ-UHFFFAOYSA-N

物化性质

• 熔点：
  219-221 °C
• 沸点：
  419.31°C (rough estimate)
• 密度：
  1.0363 (rough estimate)
• 稳定性/保质期：
  在常温常压下保持稳定，应避免与强氧化剂接触。

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 安全说明：
  S24/25
• 海关编码：
  2907299090

SDS

Name:	4 4 -(Octahydro-4 7-Methano-5h-inden-5- ylidene) Bisphenol Material Safety Data Sheet
Synonym:	None
CAS:	1943-97-1

Section 1 - Chemical Product MSDS Name:4 4 -(Octahydro-4 7-Methano-5h-inden-5- ylidene) Bisphenol Material Safety Data Sheet
Synonym:None

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
1943-97-1	Phenol,4,4'-(octahydro-4,7-methano-5h-	ca 100	217-739-1

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation. The toxicological properties of this material have not been fully investigated.
Skin:
May cause skin irritation. The toxicological properties of this material have not been fully investigated.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 1943-97-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 215 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C22H24O2
Molecular Weight: 320.42

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 1943-97-1 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Phenol,4,4'-(octahydro-4,7-methano-5h-inden-5-ylidene)is- - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 1943-97-1: No information available.
Canada
CAS# 1943-97-1 is listed on Canada's NDSL List.
CAS# 1943-97-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1943-97-1 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4,4'-(十氧-4,7-甲醛)双酚 在 氢氧化钾 、 乙酸酐 、 potassium carbonate 、 溶剂黄146 作用下， 以 甲醇 、 二甲基亚砜 为溶剂， 反应 24.0h， 生成 5-[4-[8-[4-[(1,3-Dioxo-2-benzofuran-5-yl)oxy]phenyl]-8-tricyclo[5.2.1.02,6]decanyl]phenoxy]-2-benzofuran-1,3-dione
  参考文献：
  名称：

  Synthesis of bulky bis(ether anhydride)s and poly(ether imide)s with bulky main-chain units

  摘要：

  一系列的双(醚酸酐)是从非常庞大的双酚合成的。聚(醚酰亚胺)是通过这些双(醚酸酐)和两种二胺合成的，目的是提供一系列具有大型主链单元的聚(醚酰亚胺)。为了识别一系列可加工的高性能聚合物，这些聚合物在分子量、溶解性、玻璃转变温度和热稳定性方面进行了表征，可能对需要可溶性聚(醚酰亚胺)用于制造气体分离膜等应用非常有用。

  DOI：

  10.1039/a607709i
• 作为产物：
  描述：

  三环[5,2,1,0(2,6)]癸-8-酮 、 苯酚 在 间苯二酚 作用下， 反应 12.0h， 生成 4,4'-(十氧-4,7-甲醛)双酚
  参考文献：
  名称：

  METHODS FOR PREPARING CYCLOALKYLIDENE BISPHENOLS

  摘要：

  形成环烷基亚苯酚的方法包括：将具有下列结构的环烷酮化合物与下列结构的芳香羟基化合物在摩尔比大于或等于约20的条件下反应，其中[A]是取代或未取代的芳香基团，R1-R4独立地代表氢或碳链长度为C1-C12的烃基团；“a”和“b”是整数，其值独立地取自0-3；在存在含有大于或等于约8重量百分比的二乙烯苯交联的磺酸型离子交换树脂催化剂和从巯基化合物和间苯二酚化合物中选择的促进剂组成的群体中，形成下列结构的环烷基亚苯酚：其中[A]，R1-R4，“a”和“b”如前所述。此外，任何酸催化剂均可与间苯二酚促进剂一起使用。

  公开号：

  US20050137428A1

文献信息

• [EN] METHODS OF PREPARING NICOTINAMIDE RIBOSIDE AND DERIVATIVES THEREOF<br/>[FR] PROCÉDÉS DE PRÉPARATION DE NICOTINAMIDE RIBOSIDE ET DE SES DÉRIVÉS
  申请人：UNIV BELFAST

  公开号：WO2015014722A1

  公开（公告）日：2015-02-05

  The invention relates to methods of preparing nicotinamide riboside and derivatives thereof. In an aspect, the invention relates to a method of preparing a compound of formula (I), wherein n is 0 or 1; m is 0 or 1; Y is O or S; R1 is selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted primary or secondary amino, and substituted or unsubstituted azido; R2- R5, which may be the same or different, are each independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, and substituted or unsubstituted aryl; and X- is an anion, selected from an anion of a substituted or unsubstituted carboxylic acid, a halide, a substituted or unsubstituted sulfonate, a substituted or unsubstituted phosphate, a substituted or unsubstituted sulfate, a substituted or unsubstituted carbonate, and a substituted or unsubstituted carbamate.

  该发明涉及制备烟酰胺核糖苷及其衍生物的方法。在一个方面，该发明涉及制备化合物的方法，其化学式为(I)，其中n为0或1；m为0或1；Y为O或S；R1从H、取代或未取代的烷基、取代或未取代的烯基、取代或未取代的炔基、取代或未取代的芳基、取代或未取代的一级或二级氨基和取代或未取代的叠氮基中选择；R2-R5，可以相同也可以不同，分别独立地从H、取代或未取代的烷基、取代或未取代的烯基、取代或未取代的炔基和取代或未取代的芳基中选择；X-为阴离子，选择自取代或未取代的羧酸、卤化物、取代或未取代的磺酸盐、取代或未取代的磷酸盐、取代或未取代的硫酸盐、取代或未取代的碳酸盐和取代或未取代的氨基甲酸盐的阴离子。
• [EN] METHODS FOR PURIFYING 2-ARYL-3,3-BIS(HYDROXYARYL)PHTHALIMIDINES<br/>[FR] PROCÉDÉS DE PURIFICATION DE 2-ARYL-3,3-BIS(HYDROXYARYL)PHTHALIMIDINES
  申请人：SABIC GLOBAL TECHNOLOGIES BV

  公开号：WO2015162564A1

  公开（公告）日：2015-10-29

  Methods for synthesizing and purifying 2-aryl-3,3-bis(4-hydroxyaryl)phthalimidine compounds are provided. The method includes heating a reaction mixture including a phenolphthalein, a primary aryl amine, and an acid catalyst to form a phthalimidine; precipitating the phthalimidine from the reaction mixture to provide a crude phthalimidine; providing a solution including the crude phthalimidine, an additive, and at least one solvent; contacting the solution with one or more purification agents to provide a treated solution; precipitating and recovering a phthalimidine adduct from the treated solution; and recovering a purified phthalimidine compound from the adduct.

  提供了合成和纯化2-芳基-3,3-双(4-羟基芳基)邻苯二酰亚胺化合物的方法。该方法包括加热包括苯酞、一种主要芳基胺和酸催化剂的反应混合物以形成邻苯二酰亚胺；从反应混合物中沉淀邻苯二酰亚胺以提供粗邻苯二酰亚胺；提供包括粗邻苯二酰亚胺、添加剂和至少一种溶剂的溶液；将溶液与一种或多种纯化剂接触以提供处理后的溶液；从处理后的溶液中沉淀和回收邻苯二酰亚胺加合物；并从加合物中回收纯化的邻苯二酰亚胺化合物。
• PYRIDONE DERIVATIVES AS ACID SECRETION INHIBITORS AND PROCESS FOR PREPARATION THEREOF
  申请人：Emcure Pharmaceuticals Limited

  公开号：US20150232467A1

  公开（公告）日：2015-08-20

  The present invention relates to the preparation of stable pyridone disulphide derivatives having general formula (I) and its stereoisomers, which are useful in the treatment of gastrointestinal disorders. Pyridone disulphide derivatives (I) wherein, R 1 , R 2 and R 3 are independently alkyl, alkoxy, halogen, halogenated alkoxy, halogenated alkyl, hydrogen and could be the same or different and X is CH or N. R 1 is methyl, methoxy, fluorine, trifluoromethyl, difluoromethoxy and hydrogen, R 2 is methyl, methoxy and hydrogen, and R 3 is methyl and hydrogen.

  本发明涉及制备稳定的吡啶二硫代衍生物，其通式为(I)及其立体异构体，可用于治疗胃肠道疾病。吡啶二硫代衍生物(I)中，R1、R2和R3独立地为烷基、烷氧基、卤素、卤代烷氧基、卤代烷基、氢，可以相同也可以不同，X为CH或N。其中，R1为甲基、甲氧基、氟、三氟甲基、二氟甲氧基和氢，R2为甲基、甲氧基和氢，R3为甲基和氢。
• [EN] HIGH HEAT MONOMERS AND METHODS OF USE THEREOF<br/>[FR] MONOMÈRES À CHALEUR ÉLEVÉE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：SABIC GLOBAL TECHNOLOGIES BV

  公开号：WO2016014536A1

  公开（公告）日：2016-01-28

  High purity epoxide compounds, methods for preparing the high purity epoxide compounds, and compositions derived from the epoxide compounds are provided. Also provided are materials and articles derived from the epoxide compounds.

  本发明提供了高纯度环氧化合物、制备高纯度环氧化合物的方法以及从环氧化合物衍生的组合物。还提供了从环氧化合物衍生的材料和物品。
• [EN] METHODS FOR SYNTHESIZING HIGH PURITY EPOXY COMPOUNDS AND PRODUCTS OBTAINED THEREFROM<br/>[FR] PROCÉDÉS DE SYNTHÈSE DE COMPOSÉS ÉPOXY DE HAUTE PURETÉ ET PRODUITS OBTENUS À PARTIR DE CEUX-CI
  申请人：SABIC GLOBAL TECHNOLOGIES BV

  公开号：WO2018129012A1

  公开（公告）日：2018-07-12

  A process for preparing a diglycidyl ether of formula (1) to (9) with epichlorohydrin and a catalyst, for a time and at a temperature to provide a first reaction mixture comprising a dichlorohydrin of formula (1-d) to (9-d); adding a base to the first reaction mixture to provide a second reaction mixture over a period of 15 minutes to 3 hours; and agitating the second reaction mixture for 2 to 5 hours at 40 to 60°C, to provide an as-synthesized diglycidyl ether of formula (1) to (9) having a purity of 96 to 99% or greater as determined by high performance liquid chromatography is provided. An as-synthesized or isolated diglycidyl ether of formula (1) to (9) made by the provided process is provided. A cured composition comprising the cured product of the provided diglycidyl ether, and an article comprising the same are provided.

  本发明提供一种使用环氧氯丙烷和催化剂制备式（1）至（9）的二缩水甘油醚的方法，包括在一定的时间和温度下，以产生式（1-d）至（9-d）的二氯水合物的第一反应混合物；向第一反应混合物中加入碱，以在15分钟至3小时内形成第二反应混合物；并在40至60°C下搅拌第二反应混合物2至5小时，以提供纯度为96至99％或更高的原始合成式（1）至（9）的二缩水甘油醚，其纯度由高效液相色谱法确定。本发明还提供了由所提供的方法制备的原始合成或分离的式（1）至（9）的二缩水甘油醚。本发明还提供了由所提供的二缩水甘油醚的固化产物组成的固化组合物和包含该固化组合物的物品。