4,7,7-trimethyltricyclo[4.1.1.02,4]octane-3-carboxamide | 1027161-13-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 4,7,7-trimethyltricyclo[4.1.1.02,4]octane-3-carboxamide
• CAS: 1027161-13-2
• 化学式: C₁₂H₁₉NO
• 分子量: 193.289
• InChiKey: DGWJRSDOYBPXEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4,7,7-trimethyltricyclo[4.1.1.02,4]octane-3-carboxylic acid 生成 4,7,7-trimethyltricyclo[4.1.1.02,4]octane-3-carboxamide
  参考文献：
  名称：

  Fused cycloalkyl amides and acids and their therapeutic applications

  摘要：

  本发明涉及使用式(I)1化合物治疗癫痫、双相情感障碍、精神障碍、偏头痛、疼痛或运动障碍，并提供神经保护。

  公开号：

  US20040209859A1

文献信息

• SUBSTITUTED BICYCLO [4.1.0] HEPTANE-7-CARBOXYLIC ACID AMIDES AND DERIVATIVES THEREOF AS FOOD FLAVOR SUBSTANCES
  申请人：Looft Jan

  公开号：US20100189863A1

  公开（公告）日：2010-07-29

  The present invention relates to the use of a compound of the Formula (I) wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 denote in each case independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, or an alkenyl radical with 2 to 6 C atoms, with the proviso that at least one of the radicals R 1 , R 2 , R 7 and R 8 and at least one further of the radicals R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are not hydrogen, wherein independently of one another also two of the radicals R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 can together denote a bridge with one or more bridge C atoms; Y 1 and Y 2 denote independently of one another hydrogen, methyl or ethyl; and R a and R b denote independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, an alkenyl radical with 2 to 6 C atoms or a cycloalkyl radical with 3 to 6 C atoms as a food flavor substance.

  本发明涉及使用式（I）化合物，其中：R1、R2、R3、R4、R5、R6、R7和R8各自独立地表示氢、具有1至6个碳原子的烷基基团或具有2至6个碳原子的烯基基团，但至少其中一个基团R1、R2、R7和R8以及至少另一个基团R1、R2、R3、R4、R5、R6、R7和R8不是氢，其中R1、R2、R3、R4、R5、R6、R7和R8的两个基团也可以独立地共同表示具有一个或多个桥接碳原子的桥；Y1和Y2各自独立地表示氢、甲基或乙基；以及Ra和Rb各自独立地表示氢、具有1至6个碳原子的烷基基团、具有2至6个碳原子的烯基基团或具有3至6个碳原子的环烷基团，作为食品香味物质。
• FUSED CYCLOALKYL AMIDES AND ACIDS AND THEIR THERAPEUTIC APPLICATIONS FOR THE TREATMENT OF I.A. EPILEPSY
  申请人：Abbott Laboratories

  公开号：EP1562575A1

  公开（公告）日：2005-08-17
• US8487133B2
  申请人：——

  公开号：US8487133B2

  公开（公告）日：2013-07-16
• [EN] FUSED CYCLOALKYL AMIDES AND ACIDS AND THEIR THERAPEUTIC APPLICATIONS FOR THE TREATMENT OF I.A. EPILEPSY<br/>[FR] CYCLOALKYLAMIDES ET ACIDES CONDENSES ET LEURS APPLICATIONS THERAPEUTIQUES NOTAMMENT DANS LE TRAITEMENT DE L'EPILEPSIE
  申请人：ABBOTT LAB

  公开号：WO2004037241A1

  公开（公告）日：2004-05-06

  The present invention relates to the use of compounds of formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.
• [EN] SUBSTITUTED BICYCLO[4.1.0]HEPTANE-7-CARBOXYLIC ACID AMIDES AND DERIVATIVES THEREOF AS FOOD FLAVOR SUBSTANCES<br/>[FR] Amides d'acide bicyclo[4.1.0]heptane-7-carboxylique substitués et dérivés de ces derniers en tant que substances aromatisantes pour les aliments
  申请人：SYMRISE GMBH & CO KG

  公开号：WO2008046895A1

  公开（公告）日：2008-04-24

  [EN] The present invention relates to the use of a compound of the Formula (I) wherein: R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ denote in each case independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, or an alkenyl radical with 2 to 6 C atoms, with the proviso that at least one of the radicals R¹, R², R⁷ and R⁸ and at least one further of the radicals R¹, R², R³, R⁴, R⁵, R⁶, R⁷ a nd R⁸ are not hydrogen, wherein independently of one another also two of the radicals R¹, R², R³, R⁴, R⁵, R⁶, R⁷ a nd R⁸can together denote a bridge with one or more bridge C atoms; Y¹ and Y² denote independently of one another hydrogen, methyl or ethyl; and R^a and R^b denote independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, an alkenyl radical with 2 to 6 C atoms or a cycloalkyl radical with 3 to 6 C atoms as a food flavor substance.
  [FR] La présente invention concerne l'utilisation d'un composé de la formule (I) dans laquelle : R¹, R², R³, R⁴, R⁵, R⁶, R⁷ et R⁸ représentent dans chaque cas, indépendamment les uns des autres, de l'hydrogène, un radical alkyle comprenant 1 à 6 atomes de carbone, ou un radical alcényle comprenant 2 à 6 atomes de carbone, à condition qu'au moins un des radicaux R¹, R², R⁷ et R⁸ et au moins un autre des radicaux R¹, R², R³, R⁴, R⁵, R⁶, R⁷ et R⁸ ne soient pas de l'hydrogène. Deux des radicaux R¹, R², R³, R⁴, R⁵, R⁶, R⁷ et R⁸ _,