| 1187830-14-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1187830-14-3
• 化学式: C₄₁H₄₃NO₅
• 分子量: 629.796
• InChiKey: DWEXWPZTKFQIIK-GQVFOJIBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.47
• 重原子数：
  47.0
• 可旋转键数：
  16.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  58.18
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  、 乙烯基溴化镁 在 氯化铵 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以72%的产率得到
  参考文献：
  名称：

  Access to Ring-Expanded Analogues of 2-Amino Sugars

  摘要：

  Ring-expanded 2-N-acetylamino sugar analogs Of D-glucose, D-galactose, and D-mannose have been prepared by a new synthetic route. Aspects of the highly substituted (x-amino aldehyde intermediates made them central to the approach, First, they were accessed via diastereoselective addition of a vinyl Grignard onto protected glycosyl amines. Also, the sterics of the bis-protected amine favored the formation of only one glycoside anomer. The new analogues reported here should prove useful in the development of tools to investigate the role of 2-amino sugars in biology.

  DOI：

  10.1021/ol9018387
• 作为产物：
  描述：

  2,3,4,6-四-O-苄基-D-吡喃半乳糖 、 苄胺 在 对甲苯磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 96.0h， 以74%的产率得到
  参考文献：
  名称：

  Access to Ring-Expanded Analogues of 2-Amino Sugars

  摘要：

  Ring-expanded 2-N-acetylamino sugar analogs Of D-glucose, D-galactose, and D-mannose have been prepared by a new synthetic route. Aspects of the highly substituted (x-amino aldehyde intermediates made them central to the approach, First, they were accessed via diastereoselective addition of a vinyl Grignard onto protected glycosyl amines. Also, the sterics of the bis-protected amine favored the formation of only one glycoside anomer. The new analogues reported here should prove useful in the development of tools to investigate the role of 2-amino sugars in biology.

  DOI：

  10.1021/ol9018387