10-oxodepressin | 1213233-31-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 10-oxodepressin
• 英文别名: (1R,2E,6E,10E,14S)-3,7,11,15,15-pentamethylbicyclo[12.1.0]pentadeca-2,6,10-triene-4,9-dione
• CAS: 1213233-31-8
• 化学式: C₂₀H₂₈O₂
• 分子量: 300.441
• InChiKey: WXNGUMYXVIWRMY-JZBCTFGYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  10-hydroxydepressin 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以4.6 mg的产率得到10-oxodepressin
  参考文献：
  名称：

  Rare Casbane Diterpenoids from the Hainan Soft Coral Sinularia depressa

  摘要：

  A series of nine casbane diterpenes, compounds 5-13. exhibiting either cis or trans ring junctions were isolated from the Hainan soft coral Sinularia depressa. The structures of this group of compounds, the basic member of which was named depressin (5), were established by detailed spectroscopic analysis. In addition, the absolute configuration of the main metabolite, 10-hydroxydepressin (7), and of its epimer, 1-epi-10-hydroxydepressin (8). was determined by it combination of conformational analysis and the modified Mosher's method. A stereochemical relationship between all isolated molecules was investigated by analyzing then circular dichroism profiles. Antiproliferative and antibacterial activities of the depressins were also evaluated.

  DOI：

  10.1021/np900484k