N-Desmethylderamciclane | 174411-40-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: N-Desmethylderamciclane
• 英文别名: N-methyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenyl-2-bicyclo[2.2.1]heptanyl]oxy]ethanamine
• CAS: 174411-40-6
• 化学式: C₁₉H₂₉NO
• 分子量: 287.4
• InChiKey: KTVWFUOXICTLAW-QRQLOZEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• The use of( a) bicycloheptane derivative(s)
  申请人：EGIS GYOGYSZERGYAR RT.

  公开号：EP0694299A1

  公开（公告）日：1996-01-31

  The subject matter of the invention is the use of [a] bicycloheptane derivative(s) of formula wherein Rrepresents a phenyl or a benzyl group, R₁ and R₂ ,which may be the same or different stand for straight or branched chained alkyl groups or one of R₁ and R₂ is hydrogen and the other is a straight or branched chained alkyl group, Adenotes a straight or branched chained alkylene group and ∼represents a valence bond, and [an] N-oxide(s) as well as [an] optical isomer(s) thereof and mixtures of the optical isomers and [an] acid addition salt(s) and quaternary ammonium derivative(s) of the bicycloheptane derivatives of formula I as well as [an] optical isomer(s) thereof and mixtures of the optical isomers for preparing medicaments for the treatment of diseases and disorders which are connected with the influence on the peripheral cholecystokinin (CCK) system.

  本发明的主题是使用式[a]双环庚烷衍生物 式中 R 代表苯基或苄基、 R₁ 和 R₂，可以相同或不同，代表直链或支链烷基，或 R₁ 和 R₂ 中的一个是氢，另一个是直链或支链烷基、 表示直链或支链亚烷基，以及 ∼代表价键、 式 I 的双环庚烷衍生物的[一种]N-氧化物及其[一种]光学异构体和光学异构体的混合物以及[一种]酸加成盐和季铵衍生物及其[一种]光学异构体和光学异构体的混合物，用于制备治疗与影响外周胆囊收缩素（CCK）系统有关的疾病和失调的药物。
• Therapeutic use of bicycloheptane derivatives
  申请人：NEURO3D

  公开号：EP1500391A1

  公开（公告）日：2005-01-26

  The invention refers to bicycloheptane derivatives and their use in the treatment of autism, fibromyalgia, sleep disorders, bipolar disorder, mania, obsessive compulsive disorder, social phobia, anorexia, cognition disturbances, or age related disturbances.

  本发明涉及双环庚烷衍生物及其在治疗自闭症、纤维肌痛、睡眠障碍、双相情感障碍、躁狂症、强迫症、社交恐惧症、厌食症、认知障碍或与年龄有关的障碍中的应用。
• Method for treating sexual disorders
  申请人：——

  公开号：US20020099098A1

  公开（公告）日：2002-07-25

  A method of treating sexual disorders in a mammal by administering to the mammal an effective amount of 1,7,7-trimethylbicyclo[2.2.1]heptane derivative of Formula I 1 wherein R is hydrogen or methyl, or a pharmaceutically acceptable salt thereof.

  一种治疗哺乳动物性功能障碍的方法，通过向哺乳动物施用有效量的式 I 的 1,7,7-三甲基双环[2.2.1]庚烷衍生物 1 其中 R 为氢或甲基，或其药学上可接受的盐。
• Method for treating stress or tension
  申请人：——

  公开号：US20040082665A1

  公开（公告）日：2004-04-29

  A method of treating stress and/or tension in a mammal by administering to the mammal an effective amount of 1,7,7-trimethyl-bicyclo[2.2.1]heptane derivative of Formula I 1 wherein R is hydrogen or methyl, or a pharmaceutically acceptable salt thereof.

  一种治疗哺乳动物压力和/或紧张的方法，通过向哺乳动物施用有效量的式 I 的 1,7,7-三甲基-双环[2.2.1]庚烷衍生物 1 其中 R 为氢或甲基，或其药学上可接受的盐。
• Methods for treating idiopathic hyperhidrosis and associated conditions
  申请人：——

  公开号：US20040192754A1

  公开（公告）日：2004-09-30

  The subject invention provides methods for treating symptoms and/or conditions associated with idiopathic hyperhidrosis by using compounds that decrease the activity of serotonin 5-HT2C receptors. Compounds that can ameliorate symptoms of idiopathic hyperhidrosis and associated conditions include 5-HT2C receptor antagonists (i.e., ketanserin, ritanserin, mianserin, mesulergine, cyproheptadine, fluoxetine, mirtazapine, olanzapine, and ziprasidone) as well as 5-HT2C receptor modulators (i.e., inverse agonists, partial agonists, and allosteric modulators).

  本发明提供了通过使用降低血清素5-HT2C受体活性的化合物来治疗特发性多汗症相关症状和/或病症的方法。可改善特发性多汗症症状和相关病症的化合物包括5-HT2C受体拮抗剂（即酮塞林、利坦塞林、米安塞林、美舒尔金、环丙赫普他定、氟西汀、米氮平、奥氮平和齐拉西酮）以及5-HT2C受体调节剂（即逆激动剂、部分激动剂和异位调节剂）。