methyl (E)-4-bromo-2-octenoate | 137258-02-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl (E)-4-bromo-2-octenoate
• 英文别名: methyl (E)-4-bromooct-2-enoate
• CAS: 137258-02-7
• 化学式: C₉H₁₅BrO₂
• 分子量: 235.121
• InChiKey: PZBZIEUPWPJDEA-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  methyl (E)-4-bromo-2-octenoate 在 resin IRA 900 in methoxide form 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 9.0h， 生成 methyl (E)-4-p-toluenesulfonylaminocarbonyloxy-2-octenoate
  参考文献：
  名称：

  Stereoselective Synthesis of trans-4,5-Disubstituted Oxazolidin-2-ones by Intramolecular Conjugate Addition of N-p-Toluenesulfonyl Carbamates

  摘要：

  DOI：

  10.3987/com-03-9724

文献信息

• Aerobic conversion of organic halides to alcohols. An oxygenative radical cyclization
  作者：Eiichi Nakamura、Tsuyoshi Inubushi、Satoshi Aoki、Daisuke Machii

  DOI：10.1021/ja00023a076

  日期：1991.11
• TRIPTOLIDE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF
  申请人：Hong Kong Baptist University

  公开号：US20160362691A1

  公开（公告）日：2016-12-15

  Tripyolide-nucleic acid aptamer derivatives, a preparation method and use thereof are shown. The structure of the triptolide-nucleic acid aptamer derivatives is as shown by formula I, wherein the definitions of R 1 -R 7 , G, A, B, M, Z and X are described. The present invention uses a nucleic acid aptamer and triptolide or modified compounds thereof as the starting materials, and introduces a linking group A at the C-14 hydroxyl group, epoxy groups and five-membered ring lactones in triptolide, then connects it to a nucleic acid aptamer B, and obtains the triptolide-nucleic acid aptamer derivatives. The triptolide-nucleic acid aptamer derivatives of the present invention have the characteristics of good targeting, a high anti-cancer activity, low toxicity and side effects, good water solubility and high bioavailability, and the preparation method of the present invention is scientific and reasonable and has a controllable quality and good repeatability, and is thereby suitable for production.
• US9809822B2
  申请人：——

  公开号：US9809822B2

  公开（公告）日：2017-11-07