Dialphatocopherol | 7718-59-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Dialphatocopherol
• 英文别名: (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
• CAS: 7718-59-4
• 化学式: C58H100O4
• 分子量: 861.4
• InChiKey: WUWCPAFUBHNEIE-FLMAWVMFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17.68
• 重原子数：
  62
• 可旋转键数：
  24
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Compositions and methods for reduction of inflammatory symptoms and/or biomarkers in female subjects
  申请人：——

  公开号：US20040048919A1

  公开（公告）日：2004-03-11

  Medicaments and methods for the treatment and/or amelioration of certain inflammatory symptoms related to premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), perimenopause, menopause, endometriosis, post-partum depression, or administration of hormonal contraceptives are described herein. Medicaments of the invention comprise a tocopherol, an omega-3 polyunsaturated fatty acid, such as docosahexaenoic acid (DHA), or omega-9 polyunsaturated fatty acid, optionally, a flavonoid, and, optionally, a mineral, such as magnesium. Methods for treating or ameliorating such symptoms and methods for reducing elevated CRP and/or white blood cell (WBC) associated with such conditions using medicaments of the invention are also described.

  本文描述了用于治疗和/或改善与经前期综合征（PMS）、经前期情感障碍（PMDD）、围绝经期、更年期、子宫内膜异位症、产后抑郁或服用激素避孕药有关的某些炎症症状的药物和方法。本发明的药物包括生育酚、ω-3 多不饱和脂肪酸（如二十二碳六烯酸 (DHA)）或ω-9 多不饱和脂肪酸、可选的类黄酮，以及可选的矿物质（如镁）。还描述了使用本发明药物治疗或改善此类症状的方法以及降低与此类病症相关的 CRP 和/或白细胞（WBC）升高的方法。
• COMPOSITIONS AND METHODS FOR REDUCTION OF INFLAMMATORY SYMPTOMS AND/OR BIOMARKERS IN FEMALE SUBJECTS
  申请人：Galileo Pharmaceuticals, Inc.

  公开号：EP1517667A2

  公开（公告）日：2005-03-30
• [EN] COMPOSITIONS AND METHODS FOR REDUCTION OF INFLAMMATORY SYMPTOMS AND/OR BIOMARKERS IN FEMALE SUBJECTS<br/>[FR] COMPOSITIONS ET METHODES PERMETTANT DE DIMINUER DES SYMPTOMES INFLAMMATOIRES ET/OU DES BIOMARQUEURS CHEZ DES SUJETS FEMININS
  申请人：GALILEO PHARMACEUTICALS INC

  公开号：WO2004004638A2

  公开（公告）日：2004-01-15

  Medicaments and methods for the treatment and/or amelioration of certain inflammatory symptoms related to premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), perimenopause, menopause, endometriosis, post-partum depression, or administration of hormonal contraceptives are described herein. Medicaments of the invention comprise a tocopherol, an omega-3 poly-unsaturated fatty acid, such as docosahexaenoic acid (DHA), or omega-9 polyunsaturated fatty acid, optionally, a flavonoid, and, optionally, a mineral, such as magnesium. Methods for treating or ameliorating such symptoms and methods for reducing elevated CRP and/or white blood cell (WBC) associated with such conditions using medicaments of the invention are also described.
• [EN] AGING BIOMARKERS<br/>[FR] BIOMARQUEURS DE VIEILLISSEMENT
  申请人：ECOLE POLYTECH

  公开号：WO2012164525A2

  公开（公告）日：2012-12-06

  The present invention relates to novel biomarkers for aging and healthspan, methods and uses thereof, in particular, for determining the biological age of a subject and/or preventing or delaying aging process in a subject, and kits for use in said methods.