[Cu(5-chloro-2-hydroxybenzylidene-DL-alanine-2H)(water)] | 934343-31-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: [Cu(5-chloro-2-hydroxybenzylidene-DL-alanine-2H)(water)]
• 英文别名: [Cu(SalCl-Ala)H2O]
• CAS: 934343-31-4；57299-28-2
• 化学式: C₁₀H₁₀ClCuNO₄
• 分子量: 307.193
• InChiKey: DBDOGSAXSYZPMG-ORQKEDRFSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [Cu(5-chloro-2-hydroxybenzylidene-DL-alanine-2H)(water)] 以 neat (no solvent) 为溶剂， 生成 copper(II) oxide
  参考文献：
  名称：

  Synthesis, potentiometric and antimicrobial activity studies on DL-amino acids-Schiff bases and their complexes

  摘要：

  A relationship between antimicrobial activities and the formation constants of amino acid-Schiff bases and their Cu(II) and Ni(II) complexes was studied. For this purpose, a series of Schiff bases were prepared from DL-amino acids (DL-glycine, DL-alanine) and halo aldehydes (5-chloro-2-hydroxybenzaidehyde, 5-bromo-2-hydroxybenzaldehyde). Schiff bases and their Cu(II) and Ni(II) complexes were characterized by the elemental analysis, spectral analysis, magnetic moment (at ca. 25 degrees C), molar conductivity, and thermal analysis data. The complexes were found to have general compositions [ML(H2O)]. The protonation constants of the Schiff bases and stability constants of the complexes were determined potentiometrically in a dioxane-water (1 : 1) solution at 25 degrees C and 0.1 M KCl ionic strength. Antimicrobial activities of the Schiff bases and their complexes were estimated for six bacteria, such as Bacillus cereus RSKK 863, Staphylococcus aureus ATCC 259231, Micrococcus luteus NRLL B-4375, Escherichia coli ATCC 11230, Aeromonas hydrophila 106, Pseudomonas aeroginosa ATCC 29212, and the yeast Candida albicans ATCC 10239. The role of halogen substitution on the ligands, effect of the metal ion, and stabilities of the complexes are discussed on antimicrobial activities.

  DOI：

  10.1134/s1070328406070086
• 作为产物：
  描述：

  水 、 DL-丙氨酸 、 5-氯代水杨醛 、 copper dichloride 以 甲醇 、 水 为溶剂， 生成 [Cu(5-chloro-2-hydroxybenzylidene-DL-alanine-2H)(water)]
  参考文献：
  名称：

  Synthesis, potentiometric and antimicrobial activity studies on DL-amino acids-Schiff bases and their complexes

  摘要：

  A relationship between antimicrobial activities and the formation constants of amino acid-Schiff bases and their Cu(II) and Ni(II) complexes was studied. For this purpose, a series of Schiff bases were prepared from DL-amino acids (DL-glycine, DL-alanine) and halo aldehydes (5-chloro-2-hydroxybenzaidehyde, 5-bromo-2-hydroxybenzaldehyde). Schiff bases and their Cu(II) and Ni(II) complexes were characterized by the elemental analysis, spectral analysis, magnetic moment (at ca. 25 degrees C), molar conductivity, and thermal analysis data. The complexes were found to have general compositions [ML(H2O)]. The protonation constants of the Schiff bases and stability constants of the complexes were determined potentiometrically in a dioxane-water (1 : 1) solution at 25 degrees C and 0.1 M KCl ionic strength. Antimicrobial activities of the Schiff bases and their complexes were estimated for six bacteria, such as Bacillus cereus RSKK 863, Staphylococcus aureus ATCC 259231, Micrococcus luteus NRLL B-4375, Escherichia coli ATCC 11230, Aeromonas hydrophila 106, Pseudomonas aeroginosa ATCC 29212, and the yeast Candida albicans ATCC 10239. The role of halogen substitution on the ligands, effect of the metal ion, and stabilities of the complexes are discussed on antimicrobial activities.

  DOI：

  10.1134/s1070328406070086