4-(3,5-dichlorophenoxy)-3-(4-(3,3-dimethylbutanoyl)piperazin-1-ylsulfonyl)benzonitrile | 1253108-55-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(3,5-dichlorophenoxy)-3-(4-(3,3-dimethylbutanoyl)piperazin-1-ylsulfonyl)benzonitrile
• 英文别名: 4-(3,5-Dichlorophenoxy)-3-[4-(3,3-dimethylbutanoyl)piperazin-1-yl]sulfonylbenzonitrile
• CAS: 1253108-55-2
• 化学式: C₂₃H₂₅Cl₂N₃O₄S
• 分子量: 510.441
• InChiKey: RLCFEYWBODTNOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  99.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• ARYLSULFONAMIDE CCR3 ANTAGONISTS
  申请人：Ly Tai Wei

  公开号：US20100273795A1

  公开（公告）日：2010-10-28

  Provided herein are arylsulfonamides that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3-mediated disorder, disease, or condition.

  本文提供了对调节CCR3活性有用的芳基磺酰胺及其制药组合物。同时也提供了使用这些化合物治疗、预防或改善CCR3介导的疾病、症状或状况的方法。
• Arylsulfonamide CCR3 antagonists
  申请人：Axikin Pharmaceuticals, Inc.

  公开号：EP2502921A1

  公开（公告）日：2012-09-26

  Provided herein are arylsulfonamides that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3-mediated disorder, disease, or condition.

  本文提供了可用于调节 CCR3 活性的芳基磺酰胺类药物及其药物组合物。本文还提供了使用它们治疗、预防或改善 CCR3 介导的紊乱、疾病或病症的一种或多种症状的方法。
• US8420639B2
  申请人：——

  公开号：US8420639B2

  公开（公告）日：2013-04-16
• US8658642B2
  申请人：——

  公开号：US8658642B2

  公开（公告）日：2014-02-25
• [EN] ARYLSULFONAMIDE CCR3 ANTAGONISTS<br/>[FR] ANTAGONISTES CCR3 D'ARYLSULFONAMIDES
  申请人：AXIKIN PHARMACEUTICALS INC

  公开号：WO2010123960A2

  公开（公告）日：2010-10-28

  Provided herein are arylsulfonamides that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3-mediated disorder, disease, or condition.